Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 12/20 | 0.40 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALDH5A1 | P51649 | 1/20 | 0.40 |
| ▸ | ABAT | P80404 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | FDPS | P14324 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | AOX1 | Q06278 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9452801 | 0.84 | POLB (0.38) | ALDH1A1TRIM24HPGDALDH5A1ABAT | |
| SCHEMBL36740 | 0.82 | ALDH1A1 (0.50) | ALDH1A1TRIM24HPGDALDH5A1ABAT | |
| SCHEMBL30360260 | 0.82 | ALDH1A1 (0.50) | ALDH1A1TRIM24HPGDALDH5A1ABAT | |
| SCHEMBL14045435 | 0.81 | ALDH1A1 (0.58) | ALDH1A1TRIM24HPGDALDH5A1ABAT | |
| SCHEMBL23245 | 0.79 | ALDH1A1 (0.43) | ALDH1A1TRIM24HPGDALDH5A1ABAT | |
| SCHEMBL29234008 | 0.79 | ALDH1A1 (0.43) | ALDH1A1TRIM24HPGDALDH5A1ABAT | |
| SCHEMBL17786208 | 0.79 | PTGDR2 (0.39) | ALDH1A1MAPTNPC1HTTRAB9A | |
| SCHEMBL7565321 | 0.79 | DRD2 (0.35) | ALDH1A1TDP1TSHRSMN1; SMN2MAPT | |
| SCHEMBL4493705 | 0.78 | ALDH1A1 (0.46) | ALDH1A1TRIM24HPGDALDH5A1ABAT | |
| SCHEMBL498989 | 0.78 | ALDH1A1 (0.64) | ALDH1A1TRIM24HPGDALDH5A1ABAT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7572778-B2 | recognize and bind the tubulin site: antitubulin; useful for treating pathological states which arise from or are exacerbated by cell proliferation as anticancer and/or antiangiogenic activity | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2009-08-11 | — | — | US | disclosed |