Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | PDE2A | O00408 | 6/20 | 0.35 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.35 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.34 |
| ▸ | PDE9A | O76083 | 1/20 | 0.33 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 2/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.32 |
| ▸ | CCR6 | P51684 | 1/20 | 0.32 |
| ▸ | VHL | P40337 | 1/20 | 0.32 |
| ▸ | LCAT | P04180 | 1/20 | 0.32 |
| ▸ | SPR | P35270 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13746898 | 0.85 | HSD11B1 (0.39) | PDE2APDE9ACXCR2 | |
| SCHEMBL4020404 | 0.85 | PDE2A (0.49) | PIK3CAPDE2AKDM5BPDE9API4KB | |
| SCHEMBL13746667 | 0.85 | PDE2A (0.37) | PIK3CAPDE2API4KBJAK2JAK1 | |
| SCHEMBL4023133 | 0.81 | PDE2A (0.37) | PDE2API4KBJAK2JAK1TYK2 | |
| SCHEMBL4023129 | 0.81 | PDE2A (0.37) | PDE2API4KBJAK2JAK1TYK2 | |
| SCHEMBL13747129 | 0.80 | TYMS (0.38) | PDE2A | |
| SCHEMBL13746627 | 0.76 | USP1 (0.34) | PIK3CAPDE2ASPR | |
| SCHEMBL4753259 | 0.75 | PIK3CA (0.35) | PIK3CADGAT1KDM5BPDE9API4KB | |
| SCHEMBL13746091 | 0.74 | DYRK1A (0.35) | PDE2APDE4ASPR | |
| SCHEMBL4028394 | 0.74 | BRD4 (0.38) | PDE2ASPR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009100403-A1 | SUBSTITUTED ARYL PYRIMIDINONES | NEUROGEN CORPORATION (US) | 2009-08-13 | — | — | WO | disclosed |