Sugi Predict

Sugi Predict / Compounds / SCHEMBL13748266

SCHEMBL13748266

SCHEMBL13748266

CCSc1cc(Cl)c(C(C)C)c(C#N)c1

nearest known ligand 0.40

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ MAOB P27338 5/20 0.40
▸ MAOA P21397 4/20 0.40
▸ MAPK1 P28482 1/20 0.35
▸ MCL1 Q07820 2/20 0.34
▸ PKM P14618 1/20 0.33
▸ PGK1 P00558 1/20 0.33
▸ KDM5A P29375 1/20 0.32
▸ AR P10275 4/20 0.32
▸ GAA P10253 1/20 0.32
▸ DAO P14920 1/20 0.32
▸ KDM4E B2RXH2 1/20 0.31
▸ MAPT P10636 1/20 0.31
▸ NPY1R P25929 1/20 0.31
▸ NPY2R P49146 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13748261 0.90 MAOA (0.44) MAOBMAOAMAPK1MCL1PKM
SCHEMBL13748759 0.84 SLC6A4 (0.38) MAOAMAPK1
SCHEMBL14331581 0.80 MAOB (0.37) MAOBMAOAMAPK1PKMPGK1
SCHEMBL13748798 0.80 AR (0.44) MAOBMAOAMCL1AR
SCHEMBL2397842 0.75 MAOB (0.49) MAOBMAOAPKMPGK1AR
SCHEMBL1017994 0.75 DAO (0.51) MAOBMAOAARGAADAO
SCHEMBL13755089 0.73 PKM (0.41) MAOBMAOAMAPK1MCL1PKM
SCHEMBL807523 0.72 TRPV4 (0.34) PGK1KDM5AARKDM4E
SCHEMBL26457742 0.72 ALDH1A1 (0.35) MAOBMAOAPGK1KDM5AAR
SCHEMBL15274595 0.70 ALDH1A1 (0.38) PGK1ARKDM4EMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8835423-B2 Azepine inhibitors of janus kinases INCYTE CORPORATION (US) 2014-09-16 — — US disclosed
US-20140031344-A1 AZEPINE INHIBITORS OF JANUS KINASES INCYTE CORPORATION (US) 2014-01-30 — — US disclosed
US-8563541-B2 Azepine inhibitors of Janus kinases INCYTE CORPORATION (US) 2013-10-22 — — US disclosed
US-20120329782-A1 AZEPINE INHIBITORS OF JANUS KINASES INCYTE CORPORATION (US) 2012-12-27 — — US disclosed
US-20090197869-A1 AZEPINE INHIBITORS OF JANUS KINASES INCYTE CORPORATION, A DELAWARE CORPORATION 2009-08-06 — — US disclosed
US-20090197869-A1 AZEPINE INHIBITORS OF JANUS KINASES INCYTE CORPORATION, A DELAWARE CORPORATION 2009-08-06 — — US disclosed
US-20070149506-A1 Azepine inhibitors of Janus kinases INCYTE CORPORATION 2007-06-28 — — US disclosed
US-20070149506-A1 Azepine inhibitors of Janus kinases INCYTE CORPORATION 2007-06-28 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120329782-A1 AZEPINE INHIBITORS OF JANUS KINASES JAK1, JAK3, JAK2 MAOB 3692/4885MAOA 3578/4885MAPK1 73/4885
US-20090197869-A1 AZEPINE INHIBITORS OF JANUS KINASES JAK1, JAK3, JAK2 MAOB 3692/4885MAOA 3578/4885MAPK1 73/4885
US-20070149506-A1 Azepine inhibitors of Janus kinases JAK1, JAK3, JAK2 MAOB 3692/4885MAOA 3578/4885MAPK1 73/4885
US-20140031344-A1 AZEPINE INHIBITORS OF JANUS KINASES JAK1, JAK3, JAK2 MAOB 3692/4885MAOA 3578/4885MAPK1 73/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.