Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 4/20 | 0.34 |
| ▸ | ACACB | O00763 | 1/20 | 0.33 |
| ▸ | TTR | P02766 | 1/20 | 0.33 |
| ▸ | ALB | P02768 | 1/20 | 0.33 |
| ▸ | VCAM1 | P19320 | 2/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | PGK1 | P00558 | 1/20 | 0.31 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.30 |
| ▸ | KDM5A | P29375 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL807269 | 0.87 | TTR (0.38) | ARTTRALBVCAM1ALDH1A1 | |
| SCHEMBL18552870 | 0.80 | AR (0.39) | ARTTRALBVCAM1KDM4E | |
| SCHEMBL26457742 | 0.80 | ALDH1A1 (0.35) | TRPV4ARPGK1KDM4EALDH1A1 | |
| SCHEMBL13748821 | 0.78 | AR (0.36) | TRPV4ARPGK1ALDH1A1 | |
| SCHEMBL807272 | 0.78 | MET (0.36) | ARTTRALBVCAM1ALDH1A1 | |
| SCHEMBL15274595 | 0.78 | ALDH1A1 (0.38) | TRPV4ARPGK1KDM4EALDH1A1 | |
| SCHEMBL807520 | 0.78 | TRPV4 (0.34) | TRPV4TTRALBVCAM1 | |
| SCHEMBL13748310 | 0.76 | AR (0.36) | ARKDM4EALDH1A1 | |
| SCHEMBL13748825 | 0.76 | PGR (0.34) | TRPV4ARKDM5A | |
| SCHEMBL15806352 | 0.75 | AR (0.38) | TRPV4ARTTRALBVCAM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012035039-A1 | AZABENZOTHIAZOLE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | F. HOFFMANN-LA ROCHE AG (CH) | 2012-03-22 | — | — | WO | disclosed |