SCHEMBL1831279

SCHEMBL1831279

Nc1nc2c(ncn2-n2cnc3c(N)ncnc32)c(=O)[nH]1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
XDH P47989 8/20 0.50
PNP P00491 3/20 0.47
TK1 P04183 2/20 0.47
STING1 Q86WV6 5/20 0.46
BLM P54132 2/20 0.46
USP2 O75604 1/20 0.46
TSHR P16473 1/20 0.46
EDNRA P25101 1/20 0.46
HTR2A P28223 1/20 0.46
RECQL P46063 1/20 0.46
HBB P68871 1/20 0.46
HSD17B10 Q99714 1/20 0.46
MEN1 O00255 1/20 0.44
ALDH1A1 P00352 1/20 0.44
LMNA P02545 1/20 0.44
CYP3A4 P08684 1/20 0.44
NFKB1 P19838 1/20 0.44
VCP P55072 1/20 0.44
KMT2A Q03164 1/20 0.44
SMN1; SMN2 Q16637 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL986800 0.88 XDH (0.60) XDHPNPTK1BLMUSP2
SCHEMBL15005119 0.86 XDH (0.59) XDHPNPTK1BLMUSP2
SCHEMBL1825531 0.84 XDH (0.51) XDHPNPTK1STING1BLM
SCHEMBL28886471 0.84 ADORA2A (0.40) XDHSTING1BLMMEN1ALDH1A1
SCHEMBL523465 0.80 XDH (0.47) XDHPNPTK1BLMUSP2
SCHEMBL580610 0.79 ADORA2A (0.64)
SCHEMBL27773184 0.79 ADORA2A (0.43) STING1
SCHEMBL28413958 0.78 ADORA2A (0.62)
SCHEMBL72147 0.77 XDH (0.50) XDHPNPTK1BLMUSP2
SCHEMBL556881 0.76 XDH (0.50) XDHPNPTK1BLMUSP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 120 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115287272-A Novel dye decoloring method for clone and recombinase of DyP-type peroxidase gene 浙江省农业科学院 2022-11-04 CN claimed
US-20090305284-A1 Methods for Identifying Risk of Breast Cancer and Treatments Thereof SEQUENOM, INC. (US) 2009-12-10 US claimed
US-6153404-A REGULATORY SEQUENCE LINKED TO SEQUENCE CODING FOR A HETEROLOGOUS POLYPEPTIDE; FOR CONTROLLED/INDUCIBLE GENE EXPRESSION IN RECOMBINANT SYSTEM INSTITUT PASTEUR (FR) 2000-11-28 US claimed
US-5780617-A PHOSPHORYLATION OF A PHOSPHATIDES WITH A NUCLEOTIDES NEXSTAR PHARMACEUTICALS, INC. (US) 1998-07-14 US claimed
EP-0594776-A1 PLASMID REPLICATION ORIGIN INCREASING THE NUMBER OF COPIES OF THE PLASMID CONTAINING SAID ORIGIN INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA) (FR) 1994-05-04 EP claimed
WO-1993001293-A1 PLASMID REPLICATION ORIGIN INCREASING THE NUMBER OF COPIES OF THE PLASMID CONTAINING SAID ORIGIN INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA) (FR) 1993-01-21 WO claimed
US-20240117346-A1 MODIFIED HETERO NUCLEIC ACIDS NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY (JP) 2024-04-11 US disclosed
CN-117487804-A Assembled pRNA nano delivery body for single base site-directed editing of mRNA and application of assembled pRNA nano delivery body in gene therapy 福建军生精准医疗科技有限公司 2024-02-02 CN disclosed
CN-116515963-A TJ-ARMS method for detecting base mutation and methylation analysis 汕头大学 2023-08-01 CN disclosed
WO-2023131727-A1 C-NUCLEOSIDE MONOPHOSPHATE SYNTHESIS UAB BIOMATTER DESIGNS (LT) 2023-07-13 WO disclosed
US-20230027885-A1 TARGETING GENE AMPLIFICATION IN CANCER USING TRIPLEX FORMATION AS A THERAPEUTIC STRATEGY YALE UNIVERSITY (US) 2023-01-26 US disclosed
US-20230025756-A1 INDUCTION OF REGULATORY B CELLS FOR THE TREATMENT OF IMMUNE-MEDIATED DISEASES CHILDRESS, SUSAN BOACKLE 2023-01-26 US disclosed
CN-115491418-A Second-generation sequencing panel of target genes with congenital incomplete lens dislocation and sequencing method 复旦大学附属眼耳鼻喉科医院 2022-12-20 CN disclosed
WO-1993001293-A1 PLASMID REPLICATION ORIGIN INCREASING THE NUMBER OF COPIES OF THE PLASMID CONTAINING SAID ORIGIN INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA) (FR) 1993-01-21 WO disclosed
US-5047519-A Alkynylamino-nucleotides E. I. DU PONT DE NEMOURS AND COMPANY (US) 1991-09-10 US disclosed
EP-0159264-B1 ANTIVIRAL COMPOUNDS MERCK & CO. INC. (US) 1991-07-24 EP disclosed
US-4980460-A Protected nucleosides which permit more efficient oligonucleotide syntheses COMMISSARIAT A L'ENERGIE ATOMIQUE (FR) 1990-12-25 US disclosed
US-4617304-A VIRICIDE; HERPES MERCK & CO., INC. (US) 1986-10-14 US disclosed
EP-0159264-A2 Antiviral compounds MERCK & CO. INC. (US) 1985-10-23 EP disclosed
US-3947605-A Process for preparing high yields of single cell products having reduced purine content and high nutritive value STANDARD OIL COMPANY (US) 1976-03-30 US disclosed