SCHEMBL4426345

SCHEMBL4426345

Nc1nc2c(ncn2-n2ccc(=O)[nH]c2=O)c(=O)[nH]1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
XDH P47989 9/20 0.54
PNP P00491 4/20 0.48
MEN1 O00255 2/20 0.47
KMT2A Q03164 2/20 0.47
TK1 P04183 2/20 0.45
BLM P54132 2/20 0.44
USP2 O75604 1/20 0.44
TSHR P16473 1/20 0.44
EDNRA P25101 1/20 0.44
HTR2A P28223 1/20 0.44
RECQL P46063 1/20 0.44
HBB P68871 1/20 0.44
HSD17B10 Q99714 1/20 0.44
ALDH1A1 P00352 1/20 0.43
LMNA P02545 1/20 0.43
CYP3A4 P08684 1/20 0.43
NFKB1 P19838 1/20 0.43
VCP P55072 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
HIF1A Q16665 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL986800 0.85 XDH (0.60) XDHPNPMEN1KMT2ATK1
SCHEMBL15005119 0.84 XDH (0.59) XDHPNPMEN1KMT2ATK1
SCHEMBL79000 0.81 XDH (0.51) XDHPNPMEN1KMT2ATK1
SCHEMBL27879438 0.81 CDK1 (0.41) XDH
SCHEMBL1375443 0.77 XDH (0.54) XDHPNPMEN1KMT2ATK1
SCHEMBL7513539 0.77 XDH (0.51) XDHPNPMEN1KMT2ATK1
SCHEMBL2558880 0.77 PI4KA (0.44)
SCHEMBL1825531 0.76 XDH (0.51) XDHPNPMEN1KMT2ATK1
Phosphoric Acid SCHEMBL27719141 0.76 PNP (0.49) XDHPNPHPRT1
SCHEMBL1831279 0.75 XDH (0.50) XDHPNPMEN1KMT2ATK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10913946-B2 RNA modulating oligonucleotides with improved characteristics for the treatment of Duchenne and Becker muscular dystrophy BIOMARIN TECHNOLOGIES B.V. (NL) 2021-02-09 US disclosed
US-20190194656-A1 RNA Modulating Oligonucleotides with Improved Characteristics for the Treatment of Duchenne and Becker Muscular Dystrophy BIOMARIN TECHNOLOGIES B.V. (NL) 2019-06-27 US disclosed
US-20090239213-A1 Identifying a target polynucleotide LINGVITAE AS (NO) 2009-09-24 US disclosed
EP-2013222-A2 COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF A GENE FROM THE JC VIRUS Alnylam Pharmaceuticals Inc. (US) 2009-01-14 EP disclosed
WO-2007127919-A2 COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF A GENE FROM THE JC VIRUS ALNYLAM PHARMACEUTICALS, INC. (US) 2007-11-08 WO disclosed
EP-1802769-A1 IDENTIFYING A TARGET POLYNUCLEOTIDE Lingvitae AS (NO) 2007-07-04 EP disclosed
WO-2006040550-A1 IDENTIFYING A TARGET POLYNUCLEOTIDE LINGVITAE AS (NO) 2006-04-20 WO disclosed
EP-0721458-A1 BIOPOLYMER SYNTHESIS UTILIZING SURFACE ACTIVATED, ORGANIC POLYMERS BECKMAN INSTRUMENTS, INC. (US) 1996-07-17 EP disclosed
EP-0700449-A1 INVERSE LINKAGE OLIGONUCLEOTIDES FOR CHEMICAL AND ENZYMATIC PROCESSES BECKMAN INSTRUMENTS, INC. (US) 1996-03-13 EP disclosed
EP-0677057-A1 BIOPOLYMER SYNTHESIS UTILIZING SURFACE ACTIVATED, ORGANIC POLYMERS BECKMAN INSTRUMENTS, INC. (US) 1995-10-18 EP disclosed
WO-1995014029-A1 PROTECTED OLIGONUCLEOSIDES AND THEIR USE IN HIGH YIELDING SYNTHESIS OF DNA AND ANTISENSE DNA BECKMAN INSTRUMENTS, INC. (US) 1995-05-26 WO disclosed
WO-1995011912-A2 BIOPOLYMER SYNTHESIS UTILIZING SURFACE ACTIVATED, ORGANIC POLYMERS BECKMAN INSTRUMENTS, INC. (US) 1995-05-04 WO disclosed
WO-1995009176-A1 BIOPOLYMER SYNTHESIS UTILIZING SURFACE ACTIVATED, ORGANIC POLYMERS BECKMAN INSTRUMENTS, INC. (US) 1995-04-06 WO disclosed
EP-0637314-A1 N-ACYLATED 2'-DEOXYCYTIDINES USEFUL IN OLIGONUCLEOTIDE SYNTHESIS BECKMAN INSTRUMENTS, INC. (US) 1995-02-08 EP disclosed
WO-1994024312-A2 INVERSE LINKAGE OLIGONUCLEOTIDES FOR CHEMICAL AND ENZYMATIC PROCESSES BECKMAN INSTRUMENTS, INC. (US) 1994-10-27 WO disclosed
WO-1993022326-A1 PROTECTING GROUPS USEFUL IN OLIGONUCLEOTIDE SYNTHESIS BECKMAN INSTRUMENTS, INC. (US) 1993-11-11 WO disclosed