Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 1/20 | 0.55 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.55 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.55 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.55 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.55 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.55 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.55 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.55 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.55 |
| ▸ | MAOB | P27338 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 5/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 4/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27870023 | 0.85 | XDH (0.59) | MAOBMAPTALDH1A1RAB9ANPC1 | |
| SCHEMBL1374843 | 0.83 | CLK1 (0.71) | MAOBMAPTALDH1A1RAB9ANPC1 | |
| SCHEMBL30629240 | 0.81 | RAB9A (0.63) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL3377510 | 0.81 | RAB9A (0.63) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL9523960 | 0.80 | MAPT (0.61) | MAOBMAPTALDH1A1LMNAL3MBTL1 | |
| SCHEMBL7789143 | 0.79 | MAPT (0.64) | MAOBMAPTALDH1A1RAB9ANPC1 | |
| SCHEMBL31060243 | 0.78 | FLT3 (0.71) | MAPTALDH1A1TDP1KDM4E | |
| SCHEMBL13345897 | 0.78 | MAPT (0.69) | MAOBMAPTALDH1A1RAB9ANPC1 | |
| SCHEMBL27874658 | 0.78 | RAB9A (0.61) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL31067505 | 0.78 | MAPT (0.67) | MAPTALDH1A1RAB9ANPC1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4727578-B2 | — | — | 2011-07-20 | — | — | JP | claimed |
| JP-2007501232-A | — | — | 2007-01-25 | — | — | JP | claimed |
| EP-1653944-A1 | HETEROCYCLIC COMPOUNDS USEFUL AS MALONYL-COA DECARBOXYLASE INHIBITORS | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2006-05-10 | — | — | EP | claimed |
| WO-2005011670-A1 | HETEROCYCLIC COMPOUNDS USEFUL AS MALONYL-COA DECARBOXYLASE INHIBITORS | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2005-02-10 | — | — | WO | claimed |
| US-20050026969-A1 | Heterocyclic compounds useful as malonyl-CoA decarboxylase inhibitors | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2005-02-03 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050026969-A1 | Heterocyclic compounds useful as malonyl-CoA decarboxylase inhibitors | ACACA, ACACB, PC | HDAC3 203/4885HDAC4 702/4885HDAC1 183/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.