Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.37 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.37 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.37 |
| ▸ | F10 | P00742 | 14/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.36 |
| ▸ | RELA | Q04206 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3871590 | 0.89 | F10 (0.38) | NPSR1F10KDM4EALDH1A1HPGD | |
| SCHEMBL8349167 | 0.88 | F10 (0.38) | NPSR1L3MBTL1F10KDM4EALDH1A1 | |
| SCHEMBL8346424 | 0.79 | SIRT2 (0.55) | NPSR1L3MBTL1SIRT2SIRT1SIRT3 | |
| SCHEMBL8347891 | 0.78 | L3MBTL1 (0.47) | NPSR1L3MBTL1SIRT2SIRT1SIRT3 | |
| SCHEMBL3868438 | 0.76 | F10 (0.40) | NPSR1F10KDM4EALDH1A1HPGD | |
| SCHEMBL8346380 | 0.76 | GAA (0.50) | NPSR1L3MBTL1SIRT2SIRT1SIRT3 | |
| SCHEMBL3864899 | 0.74 | F10 (0.63) | F10 | |
| SCHEMBL3868441 | 0.73 | F10 (0.40) | NPSR1F10KDM4EALDH1A1HPGD | |
| SCHEMBL27605913 | 0.73 | CA2 (0.46) | NPSR1L3MBTL1F10KDM4EALDH1A1 | |
| SCHEMBL3862457 | 0.73 | F10 (0.53) | F10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7566789-B2 | Benzimidazole derivatives | MERCK PATENT GMBH (DE) | 2009-07-28 | — | — | US | disclosed |
| US-7566789-B2 | Benzimidazole derivatives | MERCK PATENT GMBH (DE) | 2009-07-28 | — | — | US | disclosed |
| EP-1558247-B1 | BENZIMIDAZOLE DERIVATIVES | MERCK PATENT GMBH (DE) | 2008-02-20 | — | — | EP | disclosed |