Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 4/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.48 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.48 |
| ▸ | P2RY12 | Q9H244 | 2/20 | 0.48 |
| ▸ | F10 | P00742 | 3/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | TP53 | P04637 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8346713 | 0.86 | F10 (0.47) | GAAKDM4EPDE3BPDE3AP2RY12 | |
| SCHEMBL8347891 | 0.83 | L3MBTL1 (0.47) | HSD17B10F10NPSR1L3MBTL1SMN1; SMN2 | |
| SCHEMBL27605913 | 0.81 | CA2 (0.46) | GAAKDM4EF10NPSR1L3MBTL1 | |
| SCHEMBL8346424 | 0.81 | SIRT2 (0.55) | KDM4EHSD17B10NPSR1L3MBTL1PDE10A | |
| SCHEMBL27624772 | 0.79 | F10 (0.41) | GAAKDM4EHSD17B10PDE3BPDE3A | |
| SCHEMBL4687144 | 0.78 | F10 (0.40) | GAAKDM4EHSD17B10F10NPSR1 | |
| SCHEMBL13759435 | 0.76 | NPSR1 (0.41) | KDM4EHSD17B10F10NPSR1L3MBTL1 | |
| SCHEMBL27625018 | 0.74 | F10 (0.41) | KDM4EHSD17B10F10NPSR1L3MBTL1 | |
| SCHEMBL14816206 | 0.72 | PDE3B (0.57) | GAAKDM4EHSD17B10PDE3BPDE3A | |
| SCHEMBL3863014 | 0.72 | CSNK2A2 (0.49) | GAAKDM4EF10NPSR1PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7566789-B2 | Benzimidazole derivatives | MERCK PATENT GMBH (DE) | 2009-07-28 | — | — | US | disclosed |
| US-7566789-B2 | Benzimidazole derivatives | MERCK PATENT GMBH (DE) | 2009-07-28 | — | — | US | disclosed |
| EP-1558247-B1 | BENZIMIDAZOLE DERIVATIVES | MERCK PATENT GMBH (DE) | 2008-02-20 | — | — | EP | disclosed |
| WO-2004017963-A1 | BENZIMIDAZOLE DERIVATIVES | MERCK PATENT GMBH (DE) | 2004-03-04 | — | — | WO | disclosed |