Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 6/20 | 0.55 |
| ▸ | SIRT1 | Q96EB6 | 5/20 | 0.55 |
| ▸ | SIRT3 | Q9NTG7 | 2/20 | 0.55 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.51 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8347891 | 0.83 | L3MBTL1 (0.47) | SIRT2SIRT1SIRT3L3MBTL1NPSR1 | |
| SCHEMBL3863014 | 0.82 | CSNK2A2 (0.49) | NPSR1ALDH1A1KDM4EHPGDRAB9A | |
| SCHEMBL8346380 | 0.81 | GAA (0.50) | SIRT2SIRT1SIRT3L3MBTL1NPSR1 | |
| SCHEMBL11824061 | 0.80 | SIRT2 (0.56) | SIRT2SIRT1SIRT3PKN1PKN2 | |
| SCHEMBL13759435 | 0.79 | NPSR1 (0.41) | SIRT2SIRT1SIRT3L3MBTL1NPSR1 | |
| SCHEMBL17275543 | 0.78 | PKN1 (0.65) | SIRT2SIRT1SIRT3PKN1PKN2 | |
| SCHEMBL6169066 | 0.77 | HCRTR1 (0.56) | SIRT2SIRT1SIRT3PKN1PKN2 | |
| SCHEMBL27605913 | 0.76 | CA2 (0.46) | L3MBTL1NPSR1TP53ALDH1A1KDM4E | |
| SCHEMBL18668553 | 0.76 | SIRT2 (0.83) | SIRT2SIRT1SIRT3PKN1PKN2 | |
| SCHEMBL27624772 | 0.76 | F10 (0.41) | TP53ALDH1A1KDM4EHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7566789-B2 | Benzimidazole derivatives | MERCK PATENT GMBH (DE) | 2009-07-28 | — | — | US | disclosed |
| US-7566789-B2 | Benzimidazole derivatives | MERCK PATENT GMBH (DE) | 2009-07-28 | — | — | US | disclosed |
| EP-1558247-B1 | BENZIMIDAZOLE DERIVATIVES | MERCK PATENT GMBH (DE) | 2008-02-20 | — | — | EP | disclosed |
| WO-2004017963-A1 | BENZIMIDAZOLE DERIVATIVES | MERCK PATENT GMBH (DE) | 2004-03-04 | — | — | WO | disclosed |