SCHEMBL137699

SCHEMBL137699

Cc1cc([N+](=O)[O-])ccc1S(=O)(=O)Oc1ccc2nc(C#N)sc2c1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTT P42858 1/20 0.45
SMN1; SMN2 Q16637 1/20 0.45
PTPN1 P18031 2/20 0.43
CA2 P00918 1/20 0.42
CA5A P35218 1/20 0.42
APP P05067 1/20 0.41
ALPL P05186 2/20 0.41
ALPI P09923 2/20 0.41
SCD O00767 1/20 0.41
MEN1 O00255 4/20 0.40
KMT2A Q03164 4/20 0.40
NPC1 O15118 1/20 0.40
DYRK1A Q13627 1/20 0.40
ALDH1A1 P00352 1/20 0.40
CYP3A4 P08684 1/20 0.40
TSHR P16473 1/20 0.40
TDP1 Q9NUW8 1/20 0.40
MAPT P10636 2/20 0.39
PDK1 Q15118 1/20 0.39
NOD2 Q9HC29 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL140436 0.84 PTPN1 (0.43) HTTPTPN1CA2ALPLSCD
SCHEMBL138994 0.82 PTPN1 (0.43) HTTPTPN1CA2ALPLALPI
SCHEMBL12312893 0.81 CA2 (0.44) HTTSMN1; SMN2PTPN1CA2ALPL
SCHEMBL139851 0.81 ALPL (0.49) SMN1; SMN2PTPN1CA2ALPLALPI
SCHEMBL2380065 0.78 SMN1; SMN2 (0.61) HTTSMN1; SMN2CA2CA5AMEN1
SCHEMBL17856898 0.75 GPR35 (0.44) HTTSMN1; SMN2PTPN1CA2CA5A
SCHEMBL17861117 0.74 GPR35 (0.52) HTTSMN1; SMN2PTPN1CA2CA5A
SCHEMBL137698 0.74 GPR35 (0.52) HTTSMN1; SMN2PTPN1CA2CA5A
SCHEMBL183510 0.74 CA2 (0.41) SMN1; SMN2CA2CA5ASCDKMT2A
SCHEMBL12652580 0.74 SCD (0.50) HTTSMN1; SMN2PTPN1APPSCD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10889849-B2 Oxidized glutathione assay PROMEGA CORPORATION (US) 2021-01-12 US disclosed
US-20180030503-A1 OXIDIZED GLUTATHIONE ASSAY JPMORGAN CHASE BANK, N.A., AS COLLATERAL AGENT 2018-02-01 US disclosed
US-20180030503-A1 OXIDIZED GLUTATHIONE ASSAY JPMORGAN CHASE BANK, N.A., AS COLLATERAL AGENT 2018-02-01 US disclosed
US-9816127-B2 Oxidized glutathione assay PROMEGA CORPORATION (US) 2017-11-14 US disclosed
US-9816127-B2 Oxidized glutathione assay PROMEGA CORPORATION (US) 2017-11-14 US disclosed
US-9816127-B2 Oxidized glutathione assay PROMEGA CORPORATION (US) 2017-11-14 US disclosed
EP-2611929-B1 OXIDIZED GLUTATHIONE ASSAY PROMEGA CORP (US) 2016-01-13 EP disclosed
EP-2611929-B1 OXIDIZED GLUTATHIONE ASSAY PROMEGA CORP (US) 2016-01-13 EP disclosed
EP-2611929-A1 OXIDIZED GLUTATHIONE ASSAY Promega Corporation (US) 2013-07-10 EP disclosed
US-20120058501-A1 OXIDIZED GLUTATHIONE ASSAY JPMORGAN CHASE BANK, N.A., AS COLLATERAL AGENT 2012-03-08 US disclosed
US-20120058501-A1 OXIDIZED GLUTATHIONE ASSAY JPMORGAN CHASE BANK, N.A., AS COLLATERAL AGENT 2012-03-08 US disclosed
US-20120058501-A1 OXIDIZED GLUTATHIONE ASSAY JPMORGAN CHASE BANK, N.A., AS COLLATERAL AGENT 2012-03-08 US disclosed
WO-2012030960-A1 OXIDIZED GLUTATHIONE ASSAY PROMEGA CORPORATION (US) 2012-03-08 WO disclosed
WO-2012030960-A1 OXIDIZED GLUTATHIONE ASSAY PROMEGA CORPORATION (US) 2012-03-08 WO disclosed