Sugi Predict

Sugi Predict / Compounds / Coumarin

Coumarin

Coumarin

SCHEMBL1377362

O=c1ccc2ccccc2o1.c1ccc2ncccc2c1

nearest known ligand 0.67

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CA12 O43570 3/20 0.67
▸ CA1 P00915 3/20 0.67
▸ CA2 P00918 3/20 0.67
▸ CA3 P07451 3/20 0.67
▸ CA4 P22748 3/20 0.67
▸ CA7 P43166 3/20 0.67
▸ CA9 Q16790 3/20 0.67
▸ CA14 Q9ULX7 3/20 0.67
▸ CA5A P35218 2/20 0.67
▸ CA5B Q9Y2D0 2/20 0.67
▸ LMNA P02545 2/20 0.67
▸ CA6 P23280 2/20 0.67
▸ TDP1 Q9NUW8 2/20 0.67
▸ MCL1 Q07820 1/20 0.67
▸ SOST Q9BQB4 1/20 0.67
▸ ALDH1A1 P00352 6/20 0.57
▸ NCOA1 Q15788 1/20 0.51
▸ CYP19A1 P11511 2/20 0.44
▸ PGR P06401 2/20 0.42
▸ KDM4E B2RXH2 3/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Coumarin SCHEMBL30733982 1.00 CA12 (0.67) CA12CA1CA2CA3CA4
Coumarin SCHEMBL28314951 0.98 CA12 (0.65) CA12CA1CA2CA3CA4
Coumarin SCHEMBL28291423 0.90 CA12 (0.71) CA12CA1CA2CA3CA4
Coumarin SCHEMBL27603748 0.85 CA12 (0.49) CA12CA1CA2CA3CA4
Coumarin SCHEMBL29385611 0.82 CA12 (1.00) CA12CA1CA2CA3CA4
Coumarin SCHEMBL28886137 0.82 CA12 (1.00) CA12CA1CA2CA3CA4
Coumarin SCHEMBL3441294 0.82 CA12 (1.00) CA12CA1CA2CA3CA4
Coumarin SCHEMBL1038138 0.82 CA12 (1.00) CA12CA1CA2CA3CA4
Coumarin SCHEMBL621751 0.82 CA12 (1.00) CA12CA1CA2CA3CA4
Coumarin SCHEMBL6252 0.82 CA12 (1.00) CA12CA1CA2CA3CA4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 73 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113563391-B Method for synthesizing ferrocenyl coumarin quinoline compound by using composite catalyst 河南中烟工业有限责任公司 2023-11-21 — — CN claimed
CN-116332918-A Coumarin-quinoline derivative, and preparation method and application thereof 遵义医科大学珠海校区 2023-06-27 — — CN claimed
CN-110655508-B Small molecule fluorescent probe targeting living cell mitochondria and preparation method and application thereof 南京大学 2022-06-03 — — CN claimed
CN-110172075-B Novel coumarin-quinoline-platinum (II) complex and synthesis method and application thereof 玉林师范学院 2022-03-11 — — CN claimed
CN-113563391-A Method for synthesizing ferrocenyl coumarin quinoline compound by using composite catalyst 河南中烟工业有限责任公司 2021-10-29 — — CN claimed
CN-111217798-A Coumarin-quinoline derivative and synthesis method and application thereof 山西大学 2020-06-02 — — CN claimed
CN-102584841-B Quinoline coumarin derivate and preparation method and application thereof UNIV ZHEJIANG TECHNOLOGY 2014-11-12 — — CN claimed
CN-102584841-A Quinoline coumarin derivate and preparation method and application thereof UNIV ZHEJIANG TECHNOLOGY 2012-07-18 — — CN claimed
CN-118108728-A Preparation method and application of fluorine-containing condensed ring coumarin derivative 浙江工业大学 2024-05-31 — — CN disclosed
CN-117466875-A KRAS translation inhibitor and preparation method and application thereof 中山大学 2024-01-30 — — CN disclosed
CN-117466875-A KRAS translation inhibitor and preparation method and application thereof 中山大学 2024-01-30 — — CN disclosed
CN-116448742-B Nanometer sensing paper for visually detecting sulfite as well as preparation method and application thereof 甘肃省科学院传感技术研究所 2023-12-19 — — CN disclosed
CN-113563391-B Method for synthesizing ferrocenyl coumarin quinoline compound by using composite catalyst 河南中烟工业有限责任公司 2023-11-21 — — CN disclosed
CN-113563391-B Method for synthesizing ferrocenyl coumarin quinoline compound by using composite catalyst 河南中烟工业有限责任公司 2023-11-21 — — CN disclosed
US-20040186039-A1 Multiphase laundry detergent and cleaning product shaped bodies having noncompressed parts SUNDER MATTHIAS (DE) 2004-09-23 — — US disclosed
US-20040127373-A1 Detergent shaped bodies with viscoelastic phase HENKEL AG & CO. KGAA (DE) 2004-07-01 — — US disclosed
WO-2004042020-A2 METHODS FOR TREATMENT OF THIOL-CONTAINING COMPOUND DEFICIENT CONDITIONS NATIONAL JEWISH MEDICAL AND RESEARCH CENTER (US) 2004-05-21 — — WO disclosed
US-6737390-B2 MULTILAYER; PRESSING TOGETHER HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) 2004-05-18 — — US disclosed
US-20040087527-A1 Cystic fibrosis therapy; ATP-binding cassette transport modulation; glutathione concentration in epithelial lining fluid of lower respiratory tract NATIONAL JEWISH MEDICAL AND RESEARCH CENTER 2004-05-06 — — US disclosed
US-20020006890-A1 Multiphase laundry detergent and cleaning product shaped bodies having noncompressed parts HENKEL AG & CO. KGAA (DE) 2002-01-17 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040087527-A1 Cystic fibrosis therapy; ATP-binding cassette transport modulation; glutathione concentration in epithelial lining fluid of lower respiratory tract ABCC1, CFTR, ABCC2 CA12 2865/4885CA1 4199/4885CA2 1708/4885
US-20040127373-A1 Detergent shaped bodies with viscoelastic phase ABHD16A, ABHD6, PHOSPHO1 CA12 4273/4885CA1 4381/4885CA2 4482/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.