Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | WNT3 | P56703 | 1/20 | 0.39 |
| ▸ | SFRP1 | Q8N474 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15107128 | 0.83 | EPHX1 (0.46) | EPHX1EPHX2ALDH1A1WNT3SFRP1 | |
| SCHEMBL3671572 | 0.82 | SMN1; SMN2 (0.52) | LMNATHRBALDH1A1WNT3SFRP1 | |
| SCHEMBL3671569 | 0.82 | SMN1; SMN2 (0.52) | LMNATHRBALDH1A1WNT3SFRP1 | |
| SCHEMBL16082361 | 0.80 | KLK7 (0.34) | ALDH1A1WNT3SFRP1MEN1KMT2A | |
| SCHEMBL3366889 | 0.80 | KLK7 (0.34) | ALDH1A1WNT3SFRP1MEN1KMT2A | |
| SCHEMBL13779840 | 0.79 | EPHX1 (0.50) | EPHX1EPHX2LMNATHRBALDH1A1 | |
| SCHEMBL15107853 | 0.74 | LMNA (0.43) | LMNATHRBALDH1A1MEN1KMT2A | |
| SCHEMBL8002408 | 0.73 | FKBP1A (0.36) | ALDH1A1MEN1KMT2AKDM4EGAA | |
| SCHEMBL18428524 | 0.73 | EPHX1 (0.43) | EPHX1EPHX2LMNATHRBALDH1A1 | |
| SCHEMBL6670847 | 0.72 | HSD11B1 (0.57) | EPHX1LMNAPOLBSMN1; SMN2CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2666774-B1 | Beta-lactamase Inhibitors | MERCK SHARP & DOHME (US) | 2015-01-07 | — | — | EP | disclosed |
| US-20130274475-A1 | BETA-LACTAMASE INHIBITORS | MERCK SHARP & DOHME (US) | 2013-10-17 | — | — | US | disclosed |
| US-8487093-B2 | β-lactamase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2013-07-16 | — | — | US | disclosed |
| US-20110294777-A1 | BETA-LACTAMASE INHIBITORS | MERCK SHARP & DOHME CORP. | 2011-12-01 | — | — | US | disclosed |
| WO-2009091856-A2 | BETA-LACTAMASE INHIBITORS | MERCK & CO., INC. (US) | 2009-07-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110294777-A1 | BETA-LACTAMASE INHIBITORS | MGAM, RPIA, LBR | EPHX1 3302/4885EPHX2 3654/4885LMNA 534/4885 |
| US-20130274475-A1 | BETA-LACTAMASE INHIBITORS | MGAM, RPIA, XDH | EPHX1 3442/4885EPHX2 3967/4885LMNA 374/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.