Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 5/20 | 0.47 |
| ▸ | NPC1 | O15118 | 4/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.47 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.47 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.47 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.44 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.41 |
| ▸ | METAP1 | P53582 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL661640 | 0.91 | RAB9A (0.56) | LMNAPOLBRAB9ANPC1NPSR1 | |
| SCHEMBL2880191 | 0.85 | LMNA (0.54) | LMNAPOLBRAB9ANPC1RXFP1 | |
| SCHEMBL4725312 | 0.80 | SMN1; SMN2 (0.52) | LMNAPOLBRAB9ANPC1NPSR1 | |
| SCHEMBL28220374 | 0.80 | RXFP1 (0.47) | LMNAPOLBRAB9ANPC1NPSR1 | |
| SCHEMBL736662 | 0.79 | POLB (0.49) | LMNAPOLBRAB9ANPC1RXFP1 | |
| SCHEMBL2880194 | 0.79 | BRD9 (0.52) | LMNAPOLBRAB9ANPC1RXFP1 | |
| SCHEMBL24427984 | 0.79 | CXCR2 (0.48) | LMNAPOLBRAB9ANPC1NPSR1 | |
| SCHEMBL22874399 | 0.79 | HDAC1 (0.50) | LMNAPOLBRAB9ANPC1NPSR1 | |
| SCHEMBL4365913 | 0.78 | GAA (0.53) | LMNAPOLBRAB9ANPC1NPSR1 | |
| SCHEMBL15711990 | 0.78 | LMNA (0.48) | LMNAPOLBRAB9ANPC1PDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009076502-A1 | METHODS FOR THE PREPARATION OF HYDROXY-SUBSTITUTED ARYL SULFAMIDE COMPOUNDS | WYETH (US) | 2009-06-18 | — | — | WO | disclosed |
| US-20090156826-A1 | METHODS FOR THE PREPARATION OF HYDROXY-SUBSTITUTED ARYL SULFAMIDE COMPOUNDS | WYETH (US) | 2009-06-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090156826-A1 | METHODS FOR THE PREPARATION OF HYDROXY-SUBSTITUTED ARYL SULFAMIDE COMPOUNDS | SLC6A2, SLC6A4, TPH1 | LMNA 3176/4885POLB 1932/4885RAB9A 3501/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.