SCHEMBL13800604

SCHEMBL13800604

COc1cc(-c2cncc(CN3CCC(N(Cc4cccc(-c5cc(OC)c(OC)c(OC)c5)c4)c4ccc(C)cc4)CC3)c2)cc(OC)c1OC

nearest known ligand 0.43

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
TGFBR1 P36897 1/20 0.43
ACVR1 Q04771 1/20 0.43
HTR7 P34969 1/20 0.43
PTGER2 P43116 1/20 0.40
BCHE P06276 3/20 0.39
BACE1 P56817 3/20 0.39
ACHE P22303 2/20 0.39
MEN1 O00255 1/20 0.38
KMT2A Q03164 1/20 0.38
HCRTR1 O43613 2/20 0.38
HCRTR2 O43614 2/20 0.38
UBE2M P61081 1/20 0.38
DCUN1D1 Q96GG9 1/20 0.38
CCR5 P51681 1/20 0.37
SIGMAR1 Q99720 1/20 0.37
QPCT Q16769 2/20 0.37
DRD4 P21917 1/20 0.37
MAOB P27338 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL7217819 0.99 TGFBR1 (0.42) TGFBR1ACVR1HTR7PTGER2BCHE
SCHEMBL13800589 0.95 TGFBR1 (0.43) TGFBR1ACVR1HTR7BCHEBACE1
Hydrochloric Acid SCHEMBL7217937 0.94 TGFBR1 (0.43) TGFBR1ACVR1HTR7BCHEBACE1
SCHEMBL13800341 0.93 HTR7 (0.43) TGFBR1ACVR1HTR7BCHEBACE1
SCHEMBL13800778 0.93 HTR7 (0.46) TGFBR1ACVR1HTR7BCHEBACE1
SCHEMBL13800751 0.92 HTR7 (0.44) TGFBR1ACVR1HTR7BCHEBACE1
Hydrochloric Acid SCHEMBL7217713 0.92 HTR7 (0.42) TGFBR1ACVR1HTR7BCHEBACE1
SCHEMBL13800674 0.92 MCL1 (0.43) TGFBR1ACVR1HTR7PTGER2BCHE
SCHEMBL13800642 0.92 CCR5 (0.45) TGFBR1ACVR1HTR7BCHEBACE1
Hydrochloric Acid SCHEMBL7217777 0.92 HTR7 (0.46) TGFBR1ACVR1HTR7BCHEBACE1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090143430-A1 ERYTHROPOIETIN PRODUCTION ACCELERATOR KOWA CO., LTD. (JP) 2009-06-04 US disclosed
US-20090143430-A1 ERYTHROPOIETIN PRODUCTION ACCELERATOR KOWA CO., LTD. (JP) 2009-06-04 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090143430-A1 ERYTHROPOIETIN PRODUCTION ACCELERATOR EPOR, GHRHR, ARL1 TGFBR1 2250/4885ACVR1 41/4885HTR7 3747/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.