SCHEMBL13801822

SCHEMBL13801822

Cc1cc(CC(C)C)c(NC2CCCCC2)cc1NC1CCCCC1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC8 Q9BY41 1/20 0.42
MAPT P10636 3/20 0.40
ALDH1A1 P00352 3/20 0.40
LMNA P02545 2/20 0.40
SMN1; SMN2 Q16637 2/20 0.40
CRHBP P24387 1/20 0.40
CRHR2 Q13324 1/20 0.40
CYP1A2 P05177 1/20 0.36
CYP2D6 P10635 1/20 0.36
CYP2C9 P11712 1/20 0.36
CYP2C19 P33261 1/20 0.36
ALOX15 P16050 2/20 0.35
KDM4E B2RXH2 3/20 0.35
GAA P10253 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.35
AOC1 P19801 3/20 0.34
AOC3 Q16853 3/20 0.34
LRRK2 Q5S007 1/20 0.33
TP53 P04637 1/20 0.33
GFER P55789 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4471133 0.91 KDM4E (0.39) HDAC8MAPTALDH1A1LMNASMN1; SMN2
SCHEMBL19118720 0.90 HDAC8 (0.36) HDAC8MAPTALDH1A1LMNASMN1; SMN2
SCHEMBL4482706 0.78 ALOX15 (0.32) HDAC8MAPTALDH1A1ALOX15KDM4E
SCHEMBL13801609 0.78 PTGS1 (0.42) HDAC8MAPTALDH1A1LMNAALOX15
SCHEMBL13801823 0.75 LMNA (0.47) HDAC8MAPTALDH1A1LMNASMN1; SMN2
SCHEMBL26300888 0.70 PABPC1 (0.42) HDAC8ALOX15KMT2A
SCHEMBL5608474 0.67 HDAC8 (0.59) HDAC8MAPTALDH1A1LMNASMN1; SMN2
SCHEMBL5982550 0.67 MAPT (0.46) HDAC8MAPTALDH1A1LMNASMN1; SMN2
SCHEMBL2973035 0.67 ALOX15 (0.40) HDAC8MAPTALDH1A1LMNASMN1; SMN2
SCHEMBL13801653 0.67 PDE4A (0.41) MAPTALOX15KDM4EGAATP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2245123-B1 METHODS FOR PRODUCING ALKYLATED 1,3 BENZENEDIAMINE COMPOUNDS CHEMTURA CORP (US) 2017-07-19 EP disclosed
WO-2009076091-A2 ALKYLATED 1,3 BENZENEDIAMINE COMPOUNDS AND METHODS FOR PRODUCING SAME CHEMTURA CORPORATION (US) 2009-06-18 WO disclosed