Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PHGDH | O43175 | 1/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.62 |
| ▸ | GAA | P10253 | 2/20 | 0.62 |
| ▸ | LMNA | P02545 | 2/20 | 0.62 |
| ▸ | HPGD | P15428 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | POLB | P06746 | 2/20 | 0.59 |
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | STAT3 | P40763 | 1/20 | 0.57 |
| ▸ | KCNMA1 | Q12791 | 3/20 | 0.56 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | ATM | Q13315 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6962318 | 0.89 | PHGDH (0.58) | PHGDHALDH1A1GAALMNAHPGD | |
| SCHEMBL10334186 | 0.85 | KCNMA1 (0.66) | PHGDHALDH1A1SMN1; SMN2MAPTSTAT3 | |
| SCHEMBL641989 | 0.84 | PHGDH (0.77) | PHGDHALDH1A1GAALMNAHPGD | |
| SCHEMBL14007286 | 0.83 | KCNMA1 (0.71) | MAPTKCNMA1HTTNPC1RAB9A | |
| SCHEMBL8025450 | 0.83 | MEN1 (0.70) | PHGDHALDH1A1GAALMNAHPGD | |
| SCHEMBL7453746 | 0.82 | ALDH1A1 (0.74) | PHGDHALDH1A1GAALMNAHPGD | |
| SCHEMBL5221278 | 0.80 | ALDH1A1 (0.59) | PHGDHALDH1A1GAALMNAHPGD | |
| SCHEMBL641132 | 0.80 | PHGDH (0.67) | PHGDHALDH1A1LMNAPOLBKCNMA1 | |
| SCHEMBL11627129 | 0.79 | PHGDH (0.66) | PHGDHALDH1A1GAALMNAHPGD | |
| SCHEMBL16431342 | 0.79 | LMNA (0.51) | ALDH1A1LMNASMN1; SMN2POLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090155903-A1 | PHARMACEUTICAL COMPOSITION AND METHOD | MYRIAD GENETICS, INCORPORATED (US) | 2009-06-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090155903-A1 | PHARMACEUTICAL COMPOSITION AND METHOD | APP, PSEN2, PSEN1 | PHGDH 2862/4885ALDH1A1 2808/4885GAA 133/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.