SCHEMBL14007286

SCHEMBL14007286

O=C(Nc1ccccc1NC(=O)c1cccc(Cl)c1)c1cccc(Cl)c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
KCNMA1 Q12791 2/20 0.71
KCNK3 O14649 2/20 0.68
KCNK9 Q9NPC2 2/20 0.68
MEN1 O00255 6/20 0.65
KMT2A Q03164 6/20 0.65
L3MBTL1 Q9Y468 1/20 0.64
RAB9A P51151 2/20 0.62
NPC1 O15118 1/20 0.62
GRM5 P41594 1/20 0.59
KCNQ3 O43525 1/20 0.59
KCNQ2 O43526 1/20 0.59
KCNE1 P15382 1/20 0.59
KCNQ1 P51787 1/20 0.59
KCNQ5 Q9NR82 1/20 0.59
SLC16A3 O15427 1/20 0.59
MAPT P10636 1/20 0.59
HTT P42858 1/20 0.59
PYGL P06737 1/20 0.58
PYGM P11217 1/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19246196 0.91 KCNMA1 (0.60) KCNMA1KCNK3KCNK9MEN1KMT2A
SCHEMBL11779066 0.89 HDAC1 (0.68) KCNMA1KCNK3KCNK9MEN1KMT2A
SCHEMBL21870103 0.89 POLB (0.68) KCNMA1KCNK3KCNK9MEN1KMT2A
SCHEMBL27388520 0.87 NPC1 (0.71) KCNMA1KCNK3KCNK9MEN1KMT2A
SCHEMBL1464661 0.87 MEN1 (0.79) KCNMA1KCNK3KCNK9MEN1KMT2A
SCHEMBL28345726 0.86 KMT2A (0.69) KCNMA1KCNK3KCNK9MEN1KMT2A
SCHEMBL1307853 0.84 MEN1 (0.62) KCNMA1KCNK3KCNK9MEN1KMT2A
SCHEMBL3786882 0.84 KCNK3 (0.87) KCNK3KCNK9MEN1KMT2ARAB9A
SCHEMBL13802447 0.83 PHGDH (0.72) KCNMA1L3MBTL1RAB9ANPC1MAPT
SCHEMBL28433330 0.83 RXFP1 (0.57) KCNMA1KCNK3KCNK9MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11825845-B2 Slippery liquid-infused porous surfaces that release hydrophilic and hydrophobic agents WISCONSIN ALUMNI RESEARCH FOUNDATION 2023-11-28 US disclosed
US-20220030869-A1 Slippery Liquid-Infused Porous Surfaces that Release Hydrophilic and Hydrophobic Agents NATIONAL SCIENCE FOUNDATION 2022-02-03 US disclosed
US-11046854-B2 Slippery liquid-infused porous surfaces that prevent microbial surface fouling WISCONSIN ALUMNI RESEARCH FOUNDATION (US) 2021-06-29 US disclosed
US-20200325347-A1 SLIPPERY LIQUID-INFUSED POROUS SURFACES THAT PREVENT MICROBIAL SURFACE FOULING WISCONSIN ALUMNI RESEARCH FOUNDATION (US) 2020-10-15 US disclosed
US-10751495-B2 Patient interface KONINKLIJKE PHILIPS N.V. (NL) 2020-08-25 US disclosed
US-10557042-B2 Slippery liquid-infused porous surfaces that prevent microbial surface fouling WISCONSIN ALUMNI RESEARCH FOUNDATION (US) 2020-02-11 US disclosed
US-10322112-B2 Compound combinations for attenuation of bacterial virulence WISCONSIN ALUMNI RESEARCH FOUNDATION (US) 2019-06-18 US disclosed
US-20170231962-A1 Compound Combinations for Attenuation of Bacterial Virulence NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2017-08-17 US disclosed
US-20160317771-A1 PATIENT INTERFACE KONINKLIJKE PHILIPS N.V. 2016-11-03 US disclosed
US-20160317771-A1 PATIENT INTERFACE KONINKLIJKE PHILIPS N.V. 2016-11-03 US disclosed
US-20080287546-A1 Quorum Sensing Modulators VERTEX PHARMACEUTICALS INCORPORATED 2008-11-20 US disclosed
US-20080287546-A1 Quorum Sensing Modulators VERTEX PHARMACEUTICALS INCORPORATED 2008-11-20 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170231962-A1 Compound Combinations for Attenuation of Bacterial Virulence PNISR, PGLS, QRFPR KCNMA1 2890/4885KCNK3 4050/4885KCNK9 3511/4885
US-10557042-B2 Slippery liquid-infused porous surfaces that prevent microbial surface fouling CLPP, MSN, Q6ZSR9 KCNMA1 3029/4885KCNK3 3282/4885KCNK9 2507/4885
US-10322112-B2 Compound combinations for attenuation of bacterial virulence PNISR, BLVRB, PGLS KCNMA1 2692/4885KCNK3 3953/4885KCNK9 3640/4885
US-20200325347-A1 SLIPPERY LIQUID-INFUSED POROUS SURFACES THAT PREVENT MICROBIAL SURFACE FOULING CLPP, MSN, Q6ZSR9 KCNMA1 3029/4885KCNK3 3282/4885KCNK9 2507/4885
US-20220030869-A1 Slippery Liquid-Infused Porous Surfaces that Release Hydrophilic and Hydrophobic Agents CLPP, MSN, LIPA KCNMA1 3897/4885KCNK3 3378/4885KCNK9 3745/4885
US-11046854-B2 Slippery liquid-infused porous surfaces that prevent microbial surface fouling CLPP, MSN, Q6ZSR9 KCNMA1 3029/4885KCNK3 3282/4885KCNK9 2507/4885
US-20080287546-A1 Quorum Sensing Modulators BLVRB, Q6ZSR9, PGLS KCNMA1 3202/4885KCNK3 3592/4885KCNK9 3220/4885
US-11825845-B2 Slippery liquid-infused porous surfaces that release hydrophilic and hydrophobic agents CLPP, MSN, LIPA KCNMA1 3897/4885KCNK3 3378/4885KCNK9 3745/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.