Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRNP | P04156 | 1/20 | 0.36 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.36 |
| ▸ | MET | P08581 | 2/20 | 0.35 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.34 |
| ▸ | APOBEC3A | P31941 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | IDH1 | O75874 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.32 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.32 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13810665 | 0.81 | SMN1; SMN2 (0.48) | METRAB9AKDM4EPOLBSMN1; SMN2 | |
| SCHEMBL1163189 | 0.76 | MET (0.57) | MET | |
| SCHEMBL13810663 | 0.72 | MET (0.68) | METDYRK1BL3MBTL1 | |
| SCHEMBL13810662 | 0.69 | KDR (0.49) | METRAB9ASMN1; SMN2NPC1L3MBTL1 | |
| SCHEMBL31538786 | 0.68 | GPR84 (0.57) | RAB9AKDM4ESMN1; SMN2HSD17B10MAPT | |
| SCHEMBL26146383 | 0.67 | CALM1 (0.46) | AOC3CALM1RAB9AKDM4ETAAR1 | |
| Bromide SCHEMBL31538776 | 0.67 | GPR84 (0.56) | RAB9AKDM4ESMN1; SMN2MAPTNPC1 | |
| SCHEMBL31744906 | 0.67 | GPR84 (0.49) | RAB9AKDM4ESMN1; SMN2MAPTNPC1 | |
| SCHEMBL2014924 | 0.66 | KMT2A (0.40) | METRAB9AKDM4ESMN1; SMN2MAPT | |
| SCHEMBL18766615 | 0.65 | POLB (0.48) | PRNPMETPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090156617-A1 | Tyrosine kinase inhibitors | MERCK SHARP & DOHME CORP. | 2009-06-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090156617-A1 | Tyrosine kinase inhibitors | ABL1, ERBB2, MET | PRNP 3971/4885AOC3 3844/4885MET 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.