Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 6/20 | 0.58 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | SIRT2 | Q8IXJ6 | 4/20 | 0.53 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.51 |
| ▸ | MET | P08581 | 1/20 | 0.48 |
| ▸ | FADS1 | O60427 | 1/20 | 0.47 |
| ▸ | THRA | P10827 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | PTGES | O14684 | 1/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13812748 | 0.88 | NR1H4 (0.55) | LRRK2NR1H4SIRT2P2RX1MET | |
| SCHEMBL13812761 | 0.88 | SIRT2 (0.60) | NR1H4ALOX15SIRT2P2RX1FADS1 | |
| SCHEMBL3863657 | 0.87 | P2RX1 (0.62) | NR1H4SIRT2P2RX1FADS1 | |
| SCHEMBL13812778 | 0.87 | NR1H4 (0.54) | LRRK2NR1H4SIRT2FADS1THRB | |
| SCHEMBL13812751 | 0.86 | FADS1 (0.60) | LRRK2NR1H4SIRT2METFADS1 | |
| SCHEMBL13812547 | 0.86 | MEN1 (0.55) | NR1H4SIRT2FADS1 | |
| SCHEMBL13812760 | 0.85 | LRRK2 (0.56) | LRRK2ALOX15SIRT2P2RX1FADS1 | |
| SCHEMBL13812642 | 0.82 | P2RX1 (0.61) | NR1H4SIRT2P2RX1METFADS1 | |
| SCHEMBL13812756 | 0.81 | NR1H4 (0.55) | LRRK2NR1H4SIRT2MET | |
| SCHEMBL13812782 | 0.80 | NR1H4 (0.54) | LRRK2NR1H4ALOX15SIRT2MET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7547804-B2 | Compounds, compositions, and methods employing same | MYRIAD GENETICS, INC. (US) | 2009-06-16 | — | — | US | disclosed |
| US-7547804-B2 | Compounds, compositions, and methods employing same | MYRIAD GENETICS, INC. (US) | 2009-06-16 | — | — | US | disclosed |