Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FADS1 | O60427 | 2/20 | 0.60 |
| ▸ | RAB9A | P51151 | 4/20 | 0.57 |
| ▸ | MET | P08581 | 1/20 | 0.55 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.54 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.53 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 3/20 | 0.53 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13812749 | 0.92 | MET (0.60) | RAB9AMETLRRK2SIRT2NR1H4 | |
| SCHEMBL13812778 | 0.88 | NR1H4 (0.54) | FADS1RAB9ALRRK2SIRT2NR1H4 | |
| SCHEMBL13812750 | 0.88 | FADS1 (0.58) | FADS1RAB9AMETLRRK2NPC1 | |
| SCHEMBL13812547 | 0.87 | MEN1 (0.55) | FADS1RAB9ASIRT2NR1H4NPC1 | |
| SCHEMBL13812748 | 0.87 | NR1H4 (0.55) | FADS1METLRRK2SIRT2NR1H4 | |
| SCHEMBL13812761 | 0.87 | SIRT2 (0.60) | FADS1RAB9ASIRT2NR1H4NPC1 | |
| SCHEMBL13812759 | 0.86 | LRRK2 (0.58) | FADS1METLRRK2SIRT2NR1H4 | |
| SCHEMBL3863657 | 0.86 | P2RX1 (0.62) | FADS1RAB9ASIRT2NR1H4NPC1 | |
| SCHEMBL13812736 | 0.85 | KCNK3 (0.56) | RAB9AMETLRRK2SIRT2NR1H4 | |
| SCHEMBL13812782 | 0.82 | NR1H4 (0.54) | METLRRK2SIRT2NR1H4KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7547804-B2 | Compounds, compositions, and methods employing same | MYRIAD GENETICS, INC. (US) | 2009-06-16 | — | — | US | disclosed |
| US-7547804-B2 | Compounds, compositions, and methods employing same | MYRIAD GENETICS, INC. (US) | 2009-06-16 | — | — | US | disclosed |