Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FKBP1A | P62942 | 8/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | PIK3C3 | Q8NEB9 | 4/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.37 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23015779 | 0.76 | CYP1A2 (0.40) | MAPK1ALDH1A1LMNAHTTKMT2A | |
| SCHEMBL5464187 | 0.71 | FKBP1A (0.53) | FKBP1AMAPK1ALDH1A1LMNAHTT | |
| SCHEMBL5473695 | 0.71 | FKBP1A (0.53) | FKBP1AMAPK1ALDH1A1LMNAHTT | |
| SCHEMBL30988530 | 0.70 | PIK3C3 (0.46) | FKBP1AMAPK1ALDH1A1LMNAHTT | |
| SCHEMBL12356602 | 0.69 | FLT3 (0.40) | HRH4 | |
| SCHEMBL5476374 | 0.69 | ALDH1A1 (0.46) | FKBP1AMAPK1ALDH1A1LMNAHTT | |
| SCHEMBL5473684 | 0.69 | ALDH1A1 (0.46) | FKBP1AMAPK1ALDH1A1LMNAHTT | |
| SCHEMBL1380781 | 0.69 | L3MBTL1 (0.55) | ALDH1A1LMNAKMT2AKDM4E | |
| SCHEMBL5474154 | 0.68 | LMNA (0.58) | FKBP1AMAPK1ALDH1A1LMNAHTT | |
| SCHEMBL5471685 | 0.68 | LMNA (0.58) | FKBP1AMAPK1ALDH1A1LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4809339-B2 | — | — | 2011-11-09 | — | — | JP | claimed |
| EP-1763517-B1 | PYRIMIDINE DERIVATIVES AS 11BETA-HSD1 INHIBITORS | HOFFMANN LA ROCHE (CH) | 2011-05-11 | — | — | EP | claimed |
| EP-1763517-B1 | PYRIMIDINE DERIVATIVES AS 11BETA-HSD1 INHIBITORS | HOFFMANN LA ROCHE (CH) | 2011-05-11 | — | — | EP | disclosed |