Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 2/20 | 0.68 |
| ▸ | PDE4A | P27815 | 1/20 | 0.66 |
| ▸ | AGO2 | Q9UKV8 | 1/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.63 |
| ▸ | LMNA | P02545 | 1/20 | 0.63 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | PKLR | P30613 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 3/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | ATM | Q13315 | 1/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1381858 | 0.85 | PDE4A (0.73) | HSD11B1PDE4AAGO2ALDH1A1KDM4E | |
| SCHEMBL9927453 | 0.81 | HSD11B1 (1.00) | HSD11B1ALDH1A1KDM4ELMNAMEN1 | |
| Sulfisomidine SCHEMBL34791 | 0.79 | PDE4A (1.00) | PDE4AAGO2ALDH1A1KDM4ELMNA | |
| SCHEMBL1828300 | 0.79 | PDE4A (0.74) | HSD11B1PDE4AAGO2ALDH1A1KDM4E | |
| Sulfisomidine SCHEMBL284793 | 0.78 | PDE4A (0.97) | PDE4AAGO2ALDH1A1KDM4ELMNA | |
| SCHEMBL11757838 | 0.77 | PDE4A (0.69) | HSD11B1PDE4AAGO2ALDH1A1KDM4E | |
| SCHEMBL9942079 | 0.76 | KDM4E (0.68) | HSD11B1ALDH1A1KDM4ELMNAMEN1 | |
| SCHEMBL1381150 | 0.76 | HSD11B1 (0.56) | HSD11B1ALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL12010926 | 0.76 | HSD11B1 (0.68) | HSD11B1PDE4AAGO2ALDH1A1KDM4E | |
| SCHEMBL290584 | 0.75 | ALDH1A1 (0.71) | HSD11B1PDE4AAGO2ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4809339-B2 | — | — | 2011-11-09 | — | — | JP | claimed |
| EP-1763517-B1 | PYRIMIDINE DERIVATIVES AS 11BETA-HSD1 INHIBITORS | HOFFMANN LA ROCHE (CH) | 2011-05-11 | — | — | EP | claimed |
| EP-1763517-B1 | PYRIMIDINE DERIVATIVES AS 11BETA-HSD1 INHIBITORS | HOFFMANN LA ROCHE (CH) | 2011-05-11 | — | — | EP | disclosed |