Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.74 |
| ▸ | AGO2 | Q9UKV8 | 1/20 | 0.74 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.70 |
| ▸ | LMNA | P02545 | 2/20 | 0.70 |
| ▸ | GAA | P10253 | 1/20 | 0.63 |
| ▸ | MAPT | P10636 | 1/20 | 0.63 |
| ▸ | PKM | P14618 | 1/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.62 |
| ▸ | PCTP | Q9UKL6 | 1/20 | 0.60 |
| ▸ | STARD10 | Q9Y365 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 3/20 | 0.60 |
| ▸ | USP2 | O75604 | 1/20 | 0.58 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sulfisomidine SCHEMBL34791 | 0.85 | PDE4A (1.00) | PDE4AAGO2KDM4EALDH1A1LMNA | |
| SCHEMBL1381858 | 0.84 | PDE4A (0.73) | PDE4AAGO2KDM4EALDH1A1LMNA | |
| Sulfisomidine SCHEMBL284793 | 0.84 | PDE4A (0.97) | PDE4AAGO2KDM4EALDH1A1LMNA | |
| SCHEMBL11757838 | 0.82 | PDE4A (0.69) | PDE4AAGO2KDM4EALDH1A1LMNA | |
| SCHEMBL5453637 | 0.80 | PDE4A (0.71) | PDE4AAGO2KDM4EALDH1A1LMNA | |
| SCHEMBL290584 | 0.80 | ALDH1A1 (0.71) | PDE4AAGO2KDM4EALDH1A1LMNA | |
| SCHEMBL1381435 | 0.79 | HSD11B1 (0.68) | PDE4AAGO2KDM4EALDH1A1LMNA | |
| Sulfamethazine SCHEMBL28086389 | 0.79 | PDE4A (0.87) | PDE4AAGO2KDM4EALDH1A1LMNA | |
| SCHEMBL1235093 | 0.77 | PCTP (1.00) | ALDH1A1LMNAGAAKMT2APCTP | |
| SCHEMBL12464128 | 0.76 | POLB (0.66) | PDE4AAGO2KDM4EALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1763517-B1 | PYRIMIDINE DERIVATIVES AS 11BETA-HSD1 INHIBITORS | HOFFMANN LA ROCHE (CH) | 2011-05-11 | — | — | EP | claimed |
| US-7507733-B2 | 11b-HSD1 inhibitors for the treatment of diabetes | HOFFMANN-LA ROCHE INC. (US) | 2009-03-24 | — | — | US | claimed |