Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 2/20 | 0.41 |
| ▸ | CHUK | O15111 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 3/20 | 0.39 |
| ▸ | CCR3 | P51677 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | SCD | O00767 | 1/20 | 0.38 |
| ▸ | RORC | P51449 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13815410 | 0.86 | IKBKB (0.48) | IKBKBCHUKPDE4BKMT2AMEN1 | |
| SCHEMBL275342 | 0.85 | GPR119 (0.54) | PDE4B | |
| SCHEMBL223707 | 0.76 | GPR119 (0.45) | IKBKBCHUKPDE4BKMT2AMEN1 | |
| SCHEMBL21764928 | 0.74 | IKBKB (0.47) | IKBKBCHUKPDE4BHRH1CCR3 | |
| SCHEMBL5864797 | 0.73 | RORC (0.50) | IKBKBCHUKEGFRPDE4BHRH1 | |
| SCHEMBL275679 | 0.72 | GPR119 (0.54) | PDE4B | |
| SCHEMBL5248088 | 0.72 | EPHX2 (0.47) | HRH1KMT2AMEN1SCD | |
| SCHEMBL13764677 | 0.71 | IKBKB (0.50) | IKBKBCHUKEGFRPDE4BKMT2A | |
| SCHEMBL31276874 | 0.70 | IKBKB (0.46) | IKBKBCHUKPDE4BHRH1CCR3 | |
| SCHEMBL5864915 | 0.69 | ALDH1A1 (0.49) | IKBKBKMT2AMEN1SCDRORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009077357-A1 | SPIROINDOLINONE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-06-25 | — | — | WO | disclosed |