Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TUBB4A | P04350 | 4/20 | 0.57 |
| ▸ | TUBB | P07437 | 4/20 | 0.57 |
| ▸ | TUBA3C | P0DPH7 | 4/20 | 0.57 |
| ▸ | TUBA1B | P68363 | 4/20 | 0.57 |
| ▸ | TUBA4A | P68366 | 4/20 | 0.57 |
| ▸ | TUBB4B | P68371 | 4/20 | 0.57 |
| ▸ | TUBB3 | Q13509 | 4/20 | 0.57 |
| ▸ | TUBB2A | Q13885 | 4/20 | 0.57 |
| ▸ | TUBB8 | Q3ZCM7 | 4/20 | 0.57 |
| ▸ | TUBA3E | Q6PEY2 | 4/20 | 0.57 |
| ▸ | TUBA1A | Q71U36 | 4/20 | 0.57 |
| ▸ | TUBA1C | Q9BQE3 | 4/20 | 0.57 |
| ▸ | TUBB6 | Q9BUF5 | 4/20 | 0.57 |
| ▸ | TUBB2B | Q9BVA1 | 4/20 | 0.57 |
| ▸ | TUBB1 | Q9H4B7 | 4/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | CD74 | P04233 | 1/20 | 0.50 |
| ▸ | MIF | P14174 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13819988 | 0.87 | CYP19A1 (0.52) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL13819980 | 0.87 | CD74 (0.64) | ALDH1A1KDM4ECD74MIFCYP19A1 | |
| SCHEMBL9290483 | 0.82 | CYP19A1 (0.61) | ALDH1A1CYP19A1 | |
| SCHEMBL12339966 | 0.81 | TUBB4A (0.58) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL13702605 | 0.81 | TUBB4A (0.58) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL16097875 | 0.77 | HDAC1 (0.51) | TDP1CD74MIFCYP19A1HPGD | |
| SCHEMBL12339942 | 0.76 | TUBB4A (0.63) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL19699896 | 0.75 | CYP19A1 (0.70) | CD74MIFCYP19A1GPR55MEN1 | |
| SCHEMBL30991876 | 0.74 | CD74 (0.81) | CD74MIFCYP19A1GPR55MEN1 | |
| SCHEMBL28628748 | 0.74 | ALDH1A1 (0.49) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8729270-B2 | Anti-cancer compounds, synthesis thereof, and methods of using same | UNIVERSITY OF NOTRE DAME DU LAC (US) | 2014-05-20 | — | — | US | disclosed |
| US-8729270-B2 | Anti-cancer compounds, synthesis thereof, and methods of using same | UNIVERSITY OF NOTRE DAME DU LAC (US) | 2014-05-20 | — | — | US | disclosed |
| US-20120289704-A1 | ANTI-CANCER COMPOUNDS, SYNTHESIS THEREOF, AND METHODS OF USING SAME | UNIVERSITY OF NOTRE DAME DU LAC (US) | 2012-11-15 | — | — | US | disclosed |
| US-20120289704-A1 | ANTI-CANCER COMPOUNDS, SYNTHESIS THEREOF, AND METHODS OF USING SAME | UNIVERSITY OF NOTRE DAME DU LAC (US) | 2012-11-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120289704-A1 | ANTI-CANCER COMPOUNDS, SYNTHESIS THEREOF, AND METHODS OF USING SAME | MCL1, BRDT, GLS | TUBB4A 1896/4885TUBB 2384/4885TUBA3C 2253/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.