Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 2/20 | 0.40 |
| ▸ | DRD2 | P14416 | 10/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.36 |
| ▸ | HRH1 | P35367 | 2/20 | 0.36 |
| ▸ | DRD3 | P35462 | 2/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | DRD1 | P21728 | 1/20 | 0.36 |
| ▸ | DRD5 | P21918 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.36 |
| ▸ | DRD4 | P21917 | 2/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.36 |
| ▸ | HRH2 | P25021 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12121691 | 0.94 | CCR1 (0.41) | CCR1DRD2SLC6A4HRH1DRD3 | |
| SCHEMBL14420162 | 0.87 | CCR1 (0.54) | CCR1DRD2SLC6A4HRH1DRD3 | |
| SCHEMBL12121744 | 0.85 | DRD2 (0.39) | CCR1DRD2SLC6A4HRH1DRD3 | |
| SCHEMBL13824486 | 0.85 | CCR1 (0.39) | CCR1DRD2HRH1OPRM1ADRA1A | |
| SCHEMBL13824271 | 0.84 | CCR1 (0.38) | CCR1DRD2SLC6A4HRH1DRD3 | |
| SCHEMBL12121740 | 0.84 | CCR1 (0.37) | CCR1DRD2OPRM1ADRA1AOPRL1 | |
| SCHEMBL13824278 | 0.83 | CCR1 (0.38) | CCR1DRD2OPRM1ADRA1AOPRL1 | |
| SCHEMBL14579853 | 0.82 | CCR1 (0.37) | CCR1DRD2SLC6A4HRH1DRD3 | |
| SCHEMBL14420129 | 0.82 | OPRM1 (0.39) | CCR1DRD2DRD3OPRM1ADRA1A | |
| SCHEMBL10288264 | 0.82 | CCR3 (0.38) | CCR1DRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7541365-B2 | Chemokine receptor antagonists and methods of use therefor | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2009-06-02 | — | — | US | disclosed |