Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 6/20 | 1.00 |
| ▸ | SENP1 | Q9P0U3 | 4/20 | 1.00 |
| ▸ | POLB | P06746 | 3/20 | 1.00 |
| ▸ | HSD11B1 | P28845 | 3/20 | 1.00 |
| ▸ | MEN1 | O00255 | 2/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 2/20 | 1.00 |
| ▸ | PTPN2 | P17706 | 2/20 | 1.00 |
| ▸ | PTPN6 | P29350 | 2/20 | 1.00 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 1.00 |
| ▸ | USP7 | Q93009 | 2/20 | 1.00 |
| ▸ | RECQL | P46063 | 2/20 | 1.00 |
| ▸ | AKR1B10 | O60218 | 1/20 | 1.00 |
| ▸ | CTSD | P07339 | 1/20 | 1.00 |
| ▸ | PTPRF | P10586 | 1/20 | 1.00 |
| ▸ | CYP19A1 | P11511 | 1/20 | 1.00 |
| ▸ | CETP | P11597 | 1/20 | 1.00 |
| ▸ | AKR1B1 | P15121 | 1/20 | 1.00 |
| ▸ | CES1 | P23141 | 1/20 | 1.00 |
| ▸ | ACP1 | P24666 | 1/20 | 1.00 |
| ▸ | EPHX2 | P34913 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ursolic Acid SCHEMBL9883367 | 1.00 | PTPN1 (1.00) | PTPN1SENP1POLBHSD11B1MEN1 | |
| Ursolic Acid SCHEMBL15714065 | 1.00 | PTPN1 (1.00) | PTPN1SENP1POLBHSD11B1MEN1 | |
| Ursolic Acid SCHEMBL17641055 | 1.00 | PTPN1 (1.00) | PTPN1SENP1POLBHSD11B1MEN1 | |
| Ursolic Acid SCHEMBL12181611 | 1.00 | PTPN1 (1.00) | PTPN1SENP1POLBHSD11B1MEN1 | |
| Ursolic Acid SCHEMBL17381604 | 1.00 | PTPN1 (1.00) | PTPN1SENP1POLBHSD11B1MEN1 | |
| Ursolic Acid SCHEMBL23314191 | 1.00 | PTPN1 (1.00) | PTPN1SENP1POLBHSD11B1MEN1 | |
| Ursolic Acid SCHEMBL15382984 | 1.00 | PTPN1 (1.00) | PTPN1SENP1POLBHSD11B1MEN1 | |
| Ursolic Acid SCHEMBL17381767 | 1.00 | PTPN1 (1.00) | PTPN1SENP1POLBHSD11B1MEN1 | |
| Ursolic Acid SCHEMBL21819718 | 1.00 | PTPN1 (1.00) | PTPN1SENP1POLBHSD11B1MEN1 | |
| Ursolic Acid SCHEMBL18806320 | 1.00 | PTPN1 (1.00) | PTPN1SENP1POLBHSD11B1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250352604-A1 | COMPOSITIONS AND METHODS FOR IMPROVING SLEEP AND MANAGING STRESS | KARALLIEF INC (US) | 2025-11-20 | — | — | US | claimed |
| US-20240415912-A1 | COMPOSITIONS AND METHODS FOR IMMUNE HEALTH | KARALLIEF INC | 2024-12-19 | — | — | US | claimed |
| US-11931390-B1 | Compositions and methods for immune health | KARALLIEF INC | 2024-03-19 | — | — | US | claimed |
| US-20250352604-A1 | COMPOSITIONS AND METHODS FOR IMPROVING SLEEP AND MANAGING STRESS | KARALLIEF INC (US) | 2025-11-20 | — | — | US | disclosed |
| US-20250002490-A1 | BERBERINE SALTS, URSODEOXYCHOLIC SALTS AND COMBINATIONS, METHODS OF PREPARATION AND APPLICATION THEREOF | SHENZHEN HIGHTIDE BIOPHARMACEUTICAL LTD (CN) | 2025-01-02 | — | — | US | disclosed |
| US-20240415912-A1 | COMPOSITIONS AND METHODS FOR IMMUNE HEALTH | KARALLIEF INC | 2024-12-19 | — | — | US | disclosed |
| US-11976063-B2 | Pharmaceutical composition comprising berberine and ursodeoxycholic acid for the treatment of various diseases or disorders | SHENZHEN HIGHTIDE BIOPHARMACEUTICAL, LTD. (CN) | 2024-05-07 | — | — | US | disclosed |
| US-11931390-B1 | Compositions and methods for immune health | KARALLIEF INC | 2024-03-19 | — | — | US | disclosed |
| US-20230372290-A1 | FORMULATIONS COMPRISING BOTANICAL EXTRACTS | APEX BIOTECH RES PTY LTD (AU) | 2023-11-23 | — | — | US | disclosed |
| US-20230348457-A1 | BERBERINE SALTS, URSODEOXYCHOLIC SALTS AND COMBINATIONS, METHODS OF PREPARATION AND APPLICATION THEREOF | SHENZHEN HIGHTIDE BIOPHARMACEUTICAL LTD (CN) | 2023-11-02 | — | — | US | disclosed |
| US-20230295151-A1 | BERBERINE SALTS, URSODEOXYCHOLIC SALTS AND COMBINATIONS, METHODS OF PREPARATION AND APPLICATION THEREOF | SHENZHEN HIGHTIDE BIOPHARMACEUTICAL, LTD. (CN) | 2023-09-21 | — | — | US | disclosed |
| US-20210300915-A1 | BERBERINE SALTS, URSODEOXYCHOLIC SALTS AND COMBINATIONS, METHODS OF PREPARATION AND APPLICATION THEREOF | SHENZHEN HIGHTIDE BIOPHARMACEUTICAL, LTD. (CN) | 2021-09-30 | — | — | US | disclosed |
| US-10988471-B2 | Pharmaceutical composition comprising berberine ursodeoxycholic acid salt for the treatment of various diseases or disorders | SHENZHEN HIGHTIDE BIOPHARMACEUTICAL, LTD. (CN) | 2021-04-27 | — | — | US | disclosed |
| EP-3174874-B1 | BERBERINE SALTS, URSODEOXYCHOLIC SALTS AND COMBINATIONS, METHODS OF PREPARATION AND APPLICATION THEREOF | SHENZHEN HIGHTIDE BIOPHARMACEUTICAL LTD (CN) | 2020-09-02 | — | — | EP | disclosed |
| US-20190211007-A1 | BERBERINE SALTS, URSODEOXYCHOLIC SALTS AND COMBINATIONS, METHODS OF PREPARATION AND APPLICATION THEREOF | SHENZHEN HIGHTIDE BIOPHARMACEUTICAL, LTD. (CN) | 2019-07-11 | — | — | US | disclosed |
| US-10301303-B2 | Berberine salts, ursodeoxycholic salts and combinations, methods of preparation and application thereof | SHENZHEN HIGHTIDE BIOPHARMACEUTICAL, LTD. (CN) | 2019-05-28 | — | — | US | disclosed |
| EP-3124047-A1 | PENTACYCLIC TRITERPENOIDS FOR INJECTION LIPOLYSIS | Merz Pharma GmbH & Co. KGaA (DE) | 2017-02-01 | — | — | EP | disclosed |
| US-20150174213-A1 | COMPOSITIONS COMPRISING SULFORAPHANE OR A SULFORAPHANE PRECURSOR AND URSOLIC ACID | NUTRAMAX LABORATORIES, INC. | 2015-06-25 | — | — | US | disclosed |
| US-20150118305-A1 | COMPOSITIONS COMPRISING SULFORAPHANE OR A SULFORAPHANE PRECURSOR AND URSOLIC ACID | NUTRAMAX LABORATORIES, INC. | 2015-04-30 | — | — | US | disclosed |
| WO-2012154554-A1 | FATTY ACID TRITERPENE DERIVATIVES AND THEIR USES | CATABASIS PHARMACEUTICALS, INC. (US) | 2012-11-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230348457-A1 | BERBERINE SALTS, URSODEOXYCHOLIC SALTS AND COMBINATIONS, METHODS OF PREPARATION AND APPLICATION THEREOF | CYP27A1, NR1H4, CYP7A1 | PTPN1 3843/4885SENP1 2903/4885POLB 2698/4885 |
| US-20250002490-A1 | BERBERINE SALTS, URSODEOXYCHOLIC SALTS AND COMBINATIONS, METHODS OF PREPARATION AND APPLICATION THEREOF | CYP27A1, NR1H4, CYP7A1 | PTPN1 3843/4885SENP1 2903/4885POLB 2698/4885 |
| US-20190211007-A1 | BERBERINE SALTS, URSODEOXYCHOLIC SALTS AND COMBINATIONS, METHODS OF PREPARATION AND APPLICATION THEREOF | CYP27A1, NR1H4, CYP7A1 | PTPN1 3843/4885SENP1 2903/4885POLB 2698/4885 |
| US-10988471-B2 | Pharmaceutical composition comprising berberine ursodeoxycholic acid salt for the treatment of various diseases or disorders | CYP27A1, SLC10A1, NR1H4 | PTPN1 2842/4885SENP1 3393/4885POLB 2990/4885 |
| US-20230372290-A1 | FORMULATIONS COMPRISING BOTANICAL EXTRACTS | CYP11B1, CYP11B2, ABCB11 | PTPN1 967/4885SENP1 517/4885POLB 2294/4885 |
| US-20210300915-A1 | BERBERINE SALTS, URSODEOXYCHOLIC SALTS AND COMBINATIONS, METHODS OF PREPARATION AND APPLICATION THEREOF | CYP27A1, NR1H4, CYP7A1 | PTPN1 3843/4885SENP1 2903/4885POLB 2698/4885 |
| US-20230295151-A1 | BERBERINE SALTS, URSODEOXYCHOLIC SALTS AND COMBINATIONS, METHODS OF PREPARATION AND APPLICATION THEREOF | CYP27A1, NR1H4, CYP7A1 | PTPN1 3843/4885SENP1 2903/4885POLB 2698/4885 |
| US-11976063-B2 | Pharmaceutical composition comprising berberine and ursodeoxycholic acid for the treatment of various diseases or disorders | CYP27A1, NR1H4, CPT1B | PTPN1 3817/4885SENP1 3143/4885POLB 2647/4885 |
| US-10301303-B2 | Berberine salts, ursodeoxycholic salts and combinations, methods of preparation and application thereof | CYP27A1, NR1H4, CYP7A1 | PTPN1 3843/4885SENP1 2903/4885POLB 2698/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.