Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.32 |
| ▸ | MMP13 | P45452 | 1/20 | 0.32 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.31 |
| ▸ | CFB | P00751 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3978868 | 0.74 | ALDH1A1 (0.47) | SMN1; SMN2ALDH1A1TSHR | |
| SCHEMBL1842317 | 0.72 | SMN1; SMN2 (0.48) | SMN1; SMN2NISCHCFBALDH1A1TSHR | |
| SCHEMBL6515580 | 0.69 | LMNA (0.43) | SMN1; SMN2CFBALDH1A1TP53HSD17B10 | |
| Bromide SCHEMBL5635020 | 0.69 | SMN1; SMN2 (0.46) | SMN1; SMN2NISCHCFBALDH1A1TSHR | |
| SCHEMBL10339321 | 0.68 | SMN1; SMN2 (0.41) | SMN1; SMN2MMP13 | |
| SCHEMBL5635021 | 0.67 | SMN1; SMN2 (0.43) | SMN1; SMN2NISCHCFBALDH1A1TSHR | |
| SCHEMBL4500247 | 0.67 | SMN1; SMN2 (0.38) | SMN1; SMN2MMP13CFBTSHR | |
| SCHEMBL9668468 | 0.67 | ESR2 (0.47) | SMN1; SMN2ALDH1A1 | |
| SCHEMBL6515577 | 0.66 | SMN1; SMN2 (0.42) | SMN1; SMN2NISCHCFB | |
| SCHEMBL218213 | 0.65 | SMN1; SMN2 (0.50) | SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009058919-A1 | CCR5 ANTAGONISTS AS THERAPEUTIC AGENTS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-05-07 | — | — | WO | disclosed |