Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 18/20 | 0.72 |
| ▸ | ABL1 | P00519 | 9/20 | 0.72 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.72 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.72 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.72 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.72 |
| ▸ | PRKDC | P78527 | 1/20 | 0.72 |
| ▸ | RIPK2 | O43353 | 3/20 | 0.65 |
| ▸ | FYN | P06241 | 3/20 | 0.65 |
| ▸ | CSNK1D | P48730 | 3/20 | 0.65 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.65 |
| ▸ | CSK | P41240 | 2/20 | 0.65 |
| ▸ | PRKD2 | Q9BZL6 | 2/20 | 0.65 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.65 |
| ▸ | CDK2 | P24941 | 1/20 | 0.65 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.65 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.65 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.65 |
| ▸ | KDR | P35968 | 3/20 | 0.62 |
| ▸ | RET | P07949 | 2/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1964558 | 0.84 | SRC (1.00) | SRCABL1PIK3CDPIK3CAPIK3CB | |
| SCHEMBL29390926 | 0.84 | SRC (1.00) | SRCABL1PIK3CDPIK3CAPIK3CB | |
| SCHEMBL29390060 | 0.84 | SRC (1.00) | SRCABL1PIK3CDPIK3CAPIK3CB | |
| SCHEMBL409031 | 0.81 | SRC (1.00) | SRCABL1PIK3CDPIK3CAPIK3CB | |
| SCHEMBL14617289 | 0.80 | SRC (0.74) | SRCABL1PIK3CDPIK3CAPIK3CB | |
| SCHEMBL12551744 | 0.80 | SRC (0.67) | SRCABL1PIK3CDPIK3CAPIK3CB | |
| SCHEMBL173288 | 0.79 | SRC (1.00) | SRCABL1PIK3CDPIK3CAPIK3CB | |
| SCHEMBL12551746 | 0.79 | SRC (0.74) | SRCABL1PIK3CDPIK3CAPIK3CB | |
| SCHEMBL29379380 | 0.79 | SRC (1.00) | SRCABL1PIK3CDPIK3CAPIK3CB | |
| SCHEMBL29389632 | 0.79 | SRC (1.00) | SRCABL1PIK3CDPIK3CAPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9512125-B2 | Substituted pyrazolo[3.4-D] pyrimidines as anti-inflammatory agents | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2016-12-06 | — | — | US | disclosed |
| US-9512125-B2 | Substituted pyrazolo[3.4-D] pyrimidines as anti-inflammatory agents | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2016-12-06 | — | — | US | disclosed |
| US-20090124638-A1 | ANTI-INFLAMMATORY PYRAZOLOPYRIMIDINES | REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2009-05-14 | — | — | US | disclosed |
| US-20090124638-A1 | ANTI-INFLAMMATORY PYRAZOLOPYRIMIDINES | REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2009-05-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090124638-A1 | ANTI-INFLAMMATORY PYRAZOLOPYRIMIDINES | TNF, TSLP, IL1B | SRC 3920/4885ABL1 2533/4885PIK3CD 3413/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.