SCHEMBL173288

SCHEMBL173288

CC(C)(C)n1nc(-c2cccc3ccccc23)c2c(N)ncnc21

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SRC P12931 13/20 1.00
ABL1 P00519 7/20 1.00
PRKD3 O94806 5/20 1.00
PRKD2 Q9BZL6 5/20 1.00
PRKD1 Q15139 4/20 1.00
RIPK2 O43353 4/20 1.00
FYN P06241 4/20 1.00
CSK P41240 3/20 1.00
MAPK8 P45983 3/20 1.00
CSNK1D P48730 3/20 1.00
CDK2 P24941 2/20 1.00
CAMK2A Q9UQM7 2/20 1.00
PRKCE Q02156 1/20 1.00
PIK3CD O00329 1/20 0.64
PIK3CA P42336 1/20 0.64
PIK3CB P42338 1/20 0.64
PIK3CG P48736 1/20 0.64
PRKDC P78527 1/20 0.64
PRKACA P17612 3/20 0.64
CSNK1A1 P48729 3/20 0.64

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29389632 1.00 SRC (1.00) SRCABL1PRKD3PRKD2PRKD1
SCHEMBL29379380 1.00 SRC (1.00) SRCABL1PRKD3PRKD2PRKD1
Hydrochloric Acid SCHEMBL7037036 0.99 SRC (0.98) SRCABL1PRKD3PRKD2PRKD1
Hydrochloric Acid SCHEMBL30682158 0.99 SRC (0.98) SRCABL1PRKD3PRKD2PRKD1
Hydrochloric Acid SCHEMBL31031035 0.99 SRC (0.98) SRCABL1PRKD3PRKD2PRKD1
SCHEMBL12551746 0.85 SRC (0.74) SRCABL1PRKD3PRKD2PRKD1
SCHEMBL13019875 0.84 SRC (0.73) SRCABL1PRKD3PRKD2PRKD1
SCHEMBL12551755 0.84 SRC (0.73) SRCABL1PRKD3PRKD2PRKD1
SCHEMBL3611430 0.84 SRC (0.72) SRCABL1PRKD3PRKD2PRKD1
SCHEMBL12551780 0.82 SRC (0.70) SRCABL1PRKD3PRKD2PRKD1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 196 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220041603-A1 SRC INHIBITOR COMPOUNDS FOR SKELETAL MUSCLE MODULATION, METHODS AND USES THEREOF NESTLE SA (CH) 2022-02-10 US claimed
EP-3852763-A1 SRC INHIBITOR COMPOUNDS FOR SKELETAL MUSCLE MODULATION, METHODS AND USES THEREOF Société des Produits Nestlé S.A. (CH) 2021-07-28 EP claimed
CN-112566639-A SRC inhibitor compounds for skeletal muscle modulation, methods and uses thereof 雀巢产品有限公司 2021-03-26 CN claimed
US-10913932-B2 Maturation of mammalian hepatocytes TAKARA BIO EUROPE AB (SE) 2021-02-09 US claimed
WO-2020058072-A1 SRC INHIBITOR COMPOUNDS FOR SKELETAL MUSCLE MODULATION, METHODS AND USES THEREOF Société des Produits Nestlé S.A. (CH) 2020-03-26 WO claimed
US-20180022709-A1 Compositions and Methods for Treating Toxoplasmosis, Cryptosporidiosis, and Other Apicomplexan Protozoan Related Diseases NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2018-01-25 US claimed
US-9730926-B2 Combination therapy using bispecific anti-c-Met/anti-EGFR antibody and c-Src inhibitor SAMSUNG ELECTRONICS CO., LTD. (KR) 2017-08-15 US claimed
EP-2528919-B1 COMPOSITIONS AND METHODS FOR TREATING TOXOPLASMOSIS. CRYPTOSPORIDIOSIS AND OTHER APICOMPLEXAN PROTOZOAN RELATED DISEASES UNIV WASHINGTON (US) 2016-11-02 EP claimed
US-20150216972-A1 COMBINATION THERAPY USING BISPECIFIC ANTI-C-MET/ANTI-EGFR ANTIBODY AND C-SRC INHIBITOR SAMSUNG ELECTRONICS CO., LTD. (KR) 2015-08-06 US claimed
EP-2400033-B1 Method for determining sensitivity of tumor cells to tyrosine kinase inhibitor and computer program product SYSMEX CORP (JP) 2013-02-20 EP claimed
US-20110318768-A1 METHOD FOR DETERMINING SENSITIVITY OF TUMOR CELLS TO TYROSINE KINASE INHIBITOR AND COMPUTER PROGRAM PRODUCT SYSMEX CORPORATION (JP) 2011-12-29 US claimed
US-20070087982-A1 Methods of treatment and diagnosis using modulators of virus-induced cellular gene sequences OREGON HEALTH & SCIENCE UNIVERSITY 2007-04-19 US claimed
EP-1648997-A2 METHODS OF TREATMENT AND DISGNOSIS USING MODULATORS OF VIRUS-INDUCED CELLULAR GENE SEQUENCES Oregon Health and Science University (US) 2006-04-26 EP claimed
WO-2005010143-A2 METHODS OF TREATMENT AND DISGNOSIS USING MODULATORS OF VIRUS-INDUCED CELLULAR GENE SEQUENCES OREGON HEALTH AND SCIENCE UNIVERSITY (US) 2005-02-03 WO claimed
US-12533425-B2 Methods and systems using peptides for targeting and mapping human nerves in image guided surgery, diagnostics and therapeutic delivery ALUME BIOSCIENCES, INC. (US) 2026-01-27 US disclosed
US-20250312347-A1 THERAPEUTIC BENEFIT OF SUBOPTIMALLY ADMINISTERED CHEMICAL COMPOUNDS BROWN DENNIS M (US) 2025-10-09 US disclosed
US-12336993-B2 Therapeutic benefit of suboptimally administered chemical compounds BROWN DENNIS M (US) 2025-06-24 US disclosed
US-6383790-B1 PYRAZOLO(3,4-D)PYRIMIDINE BASED COMPOUND; ANTICARCINOGENIC AGENTS; ANTITUMOR AGENTS PRINCETON UNIVERSITY 2002-05-07 US disclosed
EP-1140938-A2 HIGH AFFINITY INHIBITORS FOR TARGET VALIDATION AND USES THEREOF Princeton University (US) 2001-10-10 EP disclosed
WO-2000042042-A2 HIGH AFFINITY INHIBITORS FOR TARGET VALIDATION AND USES THEREOF PRINCETON UNIVERSITY (US) 2000-07-20 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250312347-A1 THERAPEUTIC BENEFIT OF SUBOPTIMALLY ADMINISTERED CHEMICAL COMPOUNDS UNG, DPYD, TPMT SRC 1968/4885ABL1 785/4885PRKD3 1651/4885
US-20150216972-A1 COMBINATION THERAPY USING BISPECIFIC ANTI-C-MET/ANTI-EGFR ANTIBODY AND C-SRC INHIBITOR SRC, MET, EGFR SRC 1/4885ABL1 13/4885PRKD3 1216/4885
US-20220041603-A1 SRC INHIBITOR COMPOUNDS FOR SKELETAL MUSCLE MODULATION, METHODS AND USES THEREOF MYLK2, MUSK, SRC SRC 3/4885ABL1 316/4885PRKD3 94/4885
US-20070087982-A1 Methods of treatment and diagnosis using modulators of virus-induced cellular gene sequences HAVCR2, HMGB3, HMGB2 SRC 24/4885ABL1 37/4885PRKD3 2752/4885
US-20180022709-A1 Compositions and Methods for Treating Toxoplasmosis, Cryptosporidiosis, and Other Apicomplexan Protozoan Related Diseases PNCK, TXK, CILK1 SRC 132/4885ABL1 1181/4885PRKD3 58/4885
US-12336993-B2 Therapeutic benefit of suboptimally administered chemical compounds UNG, DPYD, TPMT SRC 1968/4885ABL1 785/4885PRKD3 1651/4885
US-12533425-B2 Methods and systems using peptides for targeting and mapping human nerves in image guided surgery, diagnostics and therapeutic delivery NGLY1, VGF, GAP43 SRC 4421/4885ABL1 3418/4885PRKD3 2607/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.