Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLH | Q9Y253 | 6/20 | 0.59 |
| ▸ | APP | P05067 | 4/20 | 0.53 |
| ▸ | ALOX5 | P09917 | 7/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | USP2 | O75604 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | RECQL | P46063 | 2/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.50 |
| ▸ | BCL9 | O00512 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13846215 | 0.92 | POLH (0.49) | POLHAPPALOX5BCL9CTNNB1 | |
| SCHEMBL13846223 | 0.86 | POLH (0.65) | POLHAPPALOX5MEN1KMT2A | |
| SCHEMBL13846136 | 0.85 | POLH (0.66) | POLHAPPALOX5MEN1KMT2A | |
| SCHEMBL13846225 | 0.84 | POLH (0.47) | POLHAPPALOX5MEN1KMT2A | |
| SCHEMBL13846134 | 0.80 | POLH (0.58) | POLHAPPALOX5MEN1KMT2A | |
| SCHEMBL13846231 | 0.80 | POLH (0.59) | POLHALOX5MEN1KMT2AKDM4E | |
| SCHEMBL13846138 | 0.78 | AKR1B1 (0.58) | POLHKDM4EPOLBCYP3A4GAA | |
| SCHEMBL15928803 | 0.78 | POLH (0.72) | POLHAPPALOX5MEN1KMT2A | |
| SCHEMBL25840608 | 0.77 | POLH (0.87) | POLHAPPALOX5MEN1KMT2A | |
| SCHEMBL5169608 | 0.76 | POLH (0.80) | POLHAPPALOX5MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009064485-A1 | ANTIOXIDANT FLAVONOID DERIVATIVES | TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2009-05-22 | — | — | WO | disclosed |