Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.64 |
| ▸ | RAB9A | P51151 | 4/20 | 0.64 |
| ▸ | MEN1 | O00255 | 2/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.64 |
| ▸ | POLB | P06746 | 1/20 | 0.64 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.64 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.51 |
| ▸ | GFER | P55789 | 1/20 | 0.50 |
| ▸ | NAMPT | P43490 | 1/20 | 0.44 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | LIPE | Q05469 | 1/20 | 0.41 |
| ▸ | VCP | P55072 | 1/20 | 0.41 |
| ▸ | GLS | O94925 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7043137 | 0.88 | PTPN11 (0.59) | NPC1RAB9AMEN1KMT2APOLB | |
| SCHEMBL13847812 | 0.80 | KDM4E (0.45) | NPC1RAB9AMEN1KMT2APOLB | |
| SCHEMBL1250 | 0.80 | NPC1 (0.71) | NPC1RAB9AMEN1KMT2APOLB | |
| SCHEMBL775002 | 0.80 | NAMPT (0.56) | NPC1RAB9AMEN1KMT2ANAMPT | |
| SCHEMBL14263398 | 0.80 | CYP17A1 (0.50) | PTPN11NAMPTCYP17A1PSMB8VCP | |
| SCHEMBL9263110 | 0.79 | NPC1 (0.70) | NPC1RAB9AMEN1KMT2APOLB | |
| SCHEMBL28301495 | 0.78 | RAB9A (1.00) | NPC1RAB9AMEN1KMT2APOLB | |
| SCHEMBL13055402 | 0.78 | CYP17A1 (0.59) | PTPN11NAMPTCYP17A1SMN1; SMN2PSMB8 | |
| SCHEMBL9479696 | 0.77 | MAPT (0.58) | RAB9AMEN1KMT2APOLBGFER | |
| SCHEMBL18570243 | 0.77 | CYP17A1 (0.61) | NPC1RAB9AMEN1KMT2APTPN11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090131372-A1 | PHOSPHONATE ANALOGS FOR TREATING METABOLIC DISEASES | CHEN JAMES M | 2009-05-21 | — | — | US | disclosed |
| US-7407965-B2 | Phosphonate analogs for treating metabolic diseases | GILEAD SCIENCES, INC. (US) | 2008-08-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090131372-A1 | PHOSPHONATE ANALOGS FOR TREATING METABOLIC DISEASES | PHOSPHO1, G6PC1, PC | NPC1 160/4885RAB9A 1582/4885MEN1 836/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.