Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP1 | P53582 | 4/20 | 0.51 |
| ▸ | SIRT2 | Q8IXJ6 | 4/20 | 0.44 |
| ▸ | SIRT1 | Q96EB6 | 3/20 | 0.44 |
| ▸ | SIRT3 | Q9NTG7 | 2/20 | 0.44 |
| ▸ | SIRT5 | Q9NXA8 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | USP2 | O75604 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13848523 | 0.88 | METAP1 (0.49) | METAP1ALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL13317579 | 0.74 | METAP1 (0.60) | METAP1SIRT2SIRT1SIRT3SIRT5 | |
| SCHEMBL14839892 | 0.72 | ALDH1A1 (0.53) | METAP1SIRT2SIRT1SIRT3SIRT5 | |
| SCHEMBL13109406 | 0.70 | NOX1 (0.62) | ALDH1A1MEN1MAPTKMT2ALMNA | |
| SCHEMBL16111930 | 0.70 | NOX1 (0.62) | ALDH1A1MEN1MAPTKMT2ALMNA | |
| SCHEMBL16111932 | 0.70 | NOX1 (0.62) | ALDH1A1MEN1MAPTKMT2ALMNA | |
| SCHEMBL13848519 | 0.68 | METAP1 (1.00) | METAP1SIRT2SIRT1SIRT3SIRT5 | |
| SCHEMBL4044276 | 0.68 | METAP1 (1.00) | METAP1SIRT2SIRT1SIRT3SIRT5 | |
| SCHEMBL2561256 | 0.67 | NOX1 (0.54) | ALDH1A1MEN1MAPTKMT2ALMNA | |
| SCHEMBL1876868 | 0.67 | NOX1 (0.54) | ALDH1A1MEN1MAPTKMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1305026-B1 | BARBITURIC ACID ANALOGS AS THERAPEUTIC AGENTS | NOVUSPHARMA SPA (IT) | 2009-05-13 | — | — | EP | disclosed |
| US-20080113993-A1 | BARBITURIC ACID ANALOGS AS THERAPEUTIC AGENTS | VIA ARIOSTO, 23 (IT) | 2008-05-15 | — | — | US | disclosed |
| US-20080113993-A1 | BARBITURIC ACID ANALOGS AS THERAPEUTIC AGENTS | VIA ARIOSTO, 23 (IT) | 2008-05-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080113993-A1 | BARBITURIC ACID ANALOGS AS THERAPEUTIC AGENTS | HIF1A, HIF1AN, PDGFA | METAP1 2162/4885SIRT2 904/4885SIRT1 139/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.