Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 1.00 |
| ▸ | SULT1E1 | P49888 | 1/20 | 0.52 |
| ▸ | FDPS | P14324 | 5/20 | 0.36 |
| ▸ | GGPS1 | O95749 | 2/20 | 0.36 |
| ▸ | CETP | P11597 | 5/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.32 |
| ▸ | CDC25A | P30304 | 1/20 | 0.32 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.32 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.30 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8667490 | 0.74 | TSHR (0.59) | TSHRSULT1E1FDPSGGPS1CETP | |
| SCHEMBL14880592 | 0.73 | TSHR (0.56) | TSHRSULT1E1FDPSGGPS1ALDH1A1 | |
| SCHEMBL13446724 | 0.69 | SULT1E1 (0.59) | TSHRSULT1E1CETPALDH1A1MAPT | |
| SCHEMBL13446722 | 0.68 | SULT1E1 (1.00) | TSHRSULT1E1CETPALDH1A1CYP3A4 | |
| SCHEMBL16010827 | 0.61 | TSHR (0.44) | TSHRFDPSGGPS1ALDH1A1CYP3A4 | |
| SCHEMBL16010828 | 0.61 | TSHR (0.44) | TSHRFDPSGGPS1ALDH1A1CYP3A4 | |
| SCHEMBL30697299 | 0.60 | ESR1 (0.46) | TSHRSULT1E1FDPSGGPS1ALDH1A1 | |
| SCHEMBL19770987 | 0.60 | ESR1 (0.46) | TSHRSULT1E1FDPSGGPS1CETP | |
| SCHEMBL5013007 | 0.60 | ESR1 (0.46) | TSHRSULT1E1FDPSGGPS1CETP | |
| SCHEMBL5013008 | 0.60 | ESR1 (0.46) | TSHRSULT1E1FDPSGGPS1CETP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090131401-A1 | Transcription factor modulating compounds and methods of use thereof | PARATEK PHARMACEUTICALS, INC. (US) | 2009-05-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090131401-A1 | Transcription factor modulating compounds and methods of use thereof | JUN, CREBBP, TFEB | TSHR 3810/4885SULT1E1 1450/4885FDPS 429/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.