Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | GCK | P35557 | 1/20 | 0.40 |
| ▸ | VNN1 | O95497 | 1/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10863099 | 0.75 | ALDH1A1 (0.45) | ALDH1A1MEN1KMT2AGAAMAPT | |
| SCHEMBL10716446 | 0.70 | MAPT (0.50) | ALDH1A1HPGDMEN1KMT2AGAA | |
| SCHEMBL13860332 | 0.70 | MAPT (0.46) | ALDH1A1HPGDMEN1KMT2AGAA | |
| SCHEMBL13860333 | 0.70 | MAPT (0.46) | ALDH1A1HPGDMEN1KMT2AGAA | |
| SCHEMBL45148 | 0.67 | KMT2A (0.73) | ALDH1A1MEN1KMT2AMAPTNPSR1 | |
| SCHEMBL20157091 | 0.67 | KMT2A (0.47) | ALDH1A1HPGDMEN1KMT2AGAA | |
| SCHEMBL7090975 | 0.66 | SMN1; SMN2 (0.49) | ALDH1A1HPGDMEN1KMT2AGAA | |
| SCHEMBL7090971 | 0.66 | SMN1; SMN2 (0.49) | ALDH1A1HPGDMEN1KMT2AGAA | |
| SCHEMBL10741173 | 0.66 | ALDH1A1 (0.49) | ALDH1A1HPGDMEN1KMT2AGAA | |
| SCHEMBL10741171 | 0.66 | ALDH1A1 (0.49) | ALDH1A1HPGDMEN1KMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2710006-A1 | AZAINDOLE DERIVATIVES AS TYROSINE KINASE INHIBITORS | Principia Biopharma Inc. (US) | 2014-03-26 | — | — | EP | disclosed |
| WO-2012158785-A1 | AZAINDOLE DERIVATIVES AS TYROSINE KINASE INHIBITORS | PRINCIPIA BIOPHARMA INC. (US) | 2012-11-22 | — | — | WO | disclosed |