Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYRO3 | Q06418 | 11/20 | 0.41 |
| ▸ | MERTK | Q12866 | 11/20 | 0.41 |
| ▸ | FLT3 | P36888 | 10/20 | 0.41 |
| ▸ | GAS6 | Q14393 | 10/20 | 0.41 |
| ▸ | AXL | P30530 | 4/20 | 0.41 |
| ▸ | RRM2 | P31350 | 1/20 | 0.40 |
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.39 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.36 |
| ▸ | KCNH3 | Q9ULD8 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12468718 | 0.86 | MERTK (0.44) | TYRO3MERTKFLT3GAS6AXL | |
| SCHEMBL21553939 | 0.76 | SMN1; SMN2 (0.49) | — | |
| SCHEMBL23636379 | 0.75 | RAB9A (0.39) | NPC1 | |
| SCHEMBL13736761 | 0.75 | RAB9A (0.54) | NPC1 | |
| SCHEMBL25912779 | 0.74 | TRPM8 (0.41) | CYP3A4CYP2D6KCNH2 | |
| SCHEMBL13830642 | 0.72 | RAB9A (0.37) | NPC1 | |
| SCHEMBL19010907 | 0.71 | NPC1 (0.46) | NPC1CYP3A4CYP2D6 | |
| SCHEMBL29401898 | 0.71 | HIF1A (0.42) | — | |
| SCHEMBL14197601 | 0.71 | RRM2 (0.48) | RRM2TLR8TLR7NPC1HCAR3 | |
| SCHEMBL15748102 | 0.70 | HPGDS (0.48) | NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2709668-A1 | BIO-ORTHOGONAL DRUG ACTIVATION | Koninklijke Philips N.V. (NL) | 2014-03-26 | — | — | EP | disclosed |
| WO-2012156920-A1 | BIO-ORTHOGONAL DRUG ACTIVATION | KONINKLIJKE PHILIPS ELECTRONICS N.V. (NL) | 2012-11-22 | — | — | WO | disclosed |