Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNOT7 | Q9UIV1 | 4/20 | 0.57 |
| ▸ | PARN | O95453 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.50 |
| ▸ | BRD4 | O60885 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | PDE1A | P54750 | 1/20 | 0.44 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.44 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13861874 | 0.80 | CNOT7 (0.70) | CNOT7PARNSMN1; SMN2ADORA2BRXFP1 | |
| SCHEMBL4420441 | 0.76 | CNOT7 (0.72) | CNOT7PARNSMN1; SMN2ADORA2BRXFP1 | |
| SCHEMBL8798601 | 0.75 | CNOT7 (0.76) | CNOT7PARNSMN1; SMN2ADORA2BRXFP1 | |
| SCHEMBL7975254 | 0.71 | CNOT7 (0.55) | CNOT7PARNSMN1; SMN2ADORA2BRXFP1 | |
| SCHEMBL7812404 | 0.70 | PARN (0.54) | CNOT7PARNSMN1; SMN2ADORA2BRXFP1 | |
| SCHEMBL554897 | 0.70 | CNOT7 (0.61) | CNOT7PARNSMN1; SMN2ADORA2BRXFP1 | |
| SCHEMBL555093 | 0.70 | ALDH1A1 (0.65) | CNOT7SMN1; SMN2ADORA2BRXFP1BRD4 | |
| SCHEMBL7974027 | 0.70 | CNOT7 (0.57) | CNOT7PARNSMN1; SMN2ADORA2BRXFP1 | |
| SCHEMBL554932 | 0.69 | BRD4 (0.81) | BRD4POLBALDH1A1KMT2AKDM4E | |
| SCHEMBL7989411 | 0.69 | CNOT7 (0.53) | CNOT7PARNSMN1; SMN2ADORA2BRXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1421084-B1 | POLYCYCLIC GUANINE PHOSPHODIESTERASE V INHIBITORS | SCHERING CORP (US) | 2008-05-14 | — | — | EP | disclosed |
| EP-1790652-A1 | Polycyclic guanine phosphodiesterase V inhibitors | Schering Corporation (US) | 2007-05-30 | — | — | EP | disclosed |