Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | CRHBP | P24387 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.47 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.47 |
| ▸ | CES2 | O00748 | 1/20 | 0.46 |
| ▸ | CES1 | P23141 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | MITF | O75030 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
| ▸ | CA9 | Q16790 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9242359 | 0.87 | ALDH1A1 (0.52) | ALDH1A1LMNACYP19A1MEN1KMT2A | |
| SCHEMBL2815328 | 0.84 | ALDH1A1 (0.48) | ALDH1A1LMNACYP19A1MEN1KMT2A | |
| SCHEMBL11141195 | 0.83 | MAPT (0.45) | ALDH1A1LMNACYP19A1MEN1KMT2A | |
| SCHEMBL1505948 | 0.80 | AGTR1 (0.49) | ALDH1A1LMNACYP19A1MEN1KMT2A | |
| SCHEMBL13865449 | 0.78 | VCAM1 (0.48) | ALDH1A1LMNAMEN1KMT2ACRHBP | |
| SCHEMBL4447674 | 0.78 | ALDH1A1 (0.42) | ALDH1A1LMNACYP19A1MEN1KMT2A | |
| SCHEMBL15700641 | 0.77 | ESR1 (0.49) | ALDH1A1LMNACYP19A1MEN1KMT2A | |
| SCHEMBL28680251 | 0.77 | CYP1A2 (0.46) | ALDH1A1LMNACYP19A1MEN1KMT2A | |
| SCHEMBL10506969 | 0.77 | ALDH1A1 (0.58) | ALDH1A1LMNACYP19A1MEN1KMT2A | |
| SCHEMBL8961556 | 0.77 | ALDH1A1 (0.58) | ALDH1A1LMNACYP19A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7531573-B2 | potent, selective and safe inhibitors of the Ca2+-activated potassium channel | CHILDREN'S MEDICAL CENTER CORPORATION (US) | 2009-05-12 | — | — | US | disclosed |
| US-7531573-B2 | potent, selective and safe inhibitors of the Ca2+-activated potassium channel | CHILDREN'S MEDICAL CENTER CORPORATION (US) | 2009-05-12 | — | — | US | disclosed |