Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNN4 | O15554 | 7/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.46 |
| ▸ | GSK3B | P49841 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | CES1 | P23141 | 2/20 | 0.38 |
| ▸ | CES2 | O00748 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16267608 | 0.82 | PTPN1 (0.46) | KCNN4PTPN1GSK3BCYP2C19HIF1A | |
| SCHEMBL11694976 | 0.82 | PTPN1 (0.46) | KCNN4PTPN1GSK3BCYP2C19HIF1A | |
| SCHEMBL8939158 | 0.79 | KCNN4 (0.48) | KCNN4GSK3BNPSR1CYP2C19HIF1A | |
| SCHEMBL10999607 | 0.78 | HDAC3 (0.52) | KCNN4PTPN1GSK3BCYP2C19HIF1A | |
| SCHEMBL5331416 | 0.78 | MAPT (0.55) | KCNN4PTPN1GSK3BCYP2C19HIF1A | |
| SCHEMBL11595736 | 0.78 | L3MBTL1 (0.42) | KCNN4PTPN1GSK3BNPSR1CYP2C19 | |
| SCHEMBL13828216 | 0.77 | OPRM1 (0.55) | KCNN4NPSR1CYP2C19HIF1ACYP1A2 | |
| SCHEMBL29679704 | 0.77 | KCNN4 (0.47) | KCNN4NPSR1CYP2C19HIF1ACYP1A2 | |
| SCHEMBL13868873 | 0.77 | KCNN4 (0.47) | KCNN4NPSR1CYP2C19HIF1ACYP1A2 | |
| SCHEMBL14342915 | 0.77 | KCNN4 (0.47) | KCNN4NPSR1CYP2C19HIF1ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7531573-B2 | potent, selective and safe inhibitors of the Ca2+-activated potassium channel | CHILDREN'S MEDICAL CENTER CORPORATION (US) | 2009-05-12 | — | — | US | disclosed |