Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 7/20 | 0.67 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.66 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.66 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17790248 | 0.80 | RAB9A (0.64) | HDAC8HDAC1HDAC2NOTUMALDH1A1 | |
| Hydrochloric Acid SCHEMBL23451515 | 0.79 | RAB9A (0.62) | HDAC8HDAC1HDAC2NOTUMALDH1A1 | |
| SCHEMBL19343385 | 0.74 | RAB9A (0.81) | NOTUMALDH1A1KDM4ESMN1; SMN2NPC1 | |
| SCHEMBL17788625 | 0.73 | ALDH1A1 (0.56) | HDAC8HDAC1HDAC2NOTUMALDH1A1 | |
| SCHEMBL3829426 | 0.72 | POLB (0.58) | HDAC8HDAC1HDAC2SMN1; SMN2NPC1 | |
| SCHEMBL562313 | 0.71 | ALDH1A1 (0.62) | HDAC8NOTUMALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL1897689 | 0.71 | HDAC8 (0.55) | HDAC8HDAC1HDAC2NOTUMALDH1A1 | |
| SCHEMBL864280 | 0.71 | CES1 (0.60) | HDAC8HDAC1HDAC2SMN1; SMN2NPC1 | |
| SCHEMBL8235977 | 0.71 | ALDH1A1 (0.67) | NOTUMALDH1A1KDM4ESMN1; SMN2NPC1 | |
| SCHEMBL28582160 | 0.71 | NOTUM (1.00) | HDAC8NOTUMALDH1A1KDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7517995-B2 | Thiazolyl-dihydro-cyclopentapyrazole | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-04-14 | — | — | US | disclosed |
| US-20070238730-A1 | THIAZOLYL-DIHYDRO-CYCLOPENTAPYRAZOLE | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-10-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070238730-A1 | THIAZOLYL-DIHYDRO-CYCLOPENTAPYRAZOLE | REN, ROR1, RORB | HDAC8 1980/4885HDAC1 1317/4885HDAC2 2490/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.