Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.35 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.34 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.34 |
| ▸ | TNF | P01375 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 3/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.32 |
| ▸ | HTR1B | P28222 | 1/20 | 0.32 |
| ▸ | HTR6 | P50406 | 1/20 | 0.32 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.32 |
| ▸ | WDR5 | P61964 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.32 |
| ▸ | BACE1 | P56817 | 4/20 | 0.31 |
| ▸ | CTSD | P07339 | 3/20 | 0.31 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.31 |
| ▸ | PIM1 | P11309 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13872246 | 0.89 | CYP11B1 (0.43) | CYP11B1CYP11B2 | |
| SCHEMBL13871899 | 0.85 | MCHR1 (0.37) | NOTUMLRRK2DRD2HTR6CYP11B1 | |
| SCHEMBL13871856 | 0.79 | CYP1A2 (0.35) | NOTUMPRMT5WDR77DRD2KMT2A | |
| SCHEMBL13871879 | 0.79 | HTR2C (0.37) | NOTUMDRD2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL13871851 | 0.79 | NPC1 (0.37) | NOTUMDRD2HTR6KMT2A | |
| SCHEMBL13872258 | 0.77 | LRRK2 (0.41) | LRRK2TNFDRD2HTR1BHTR6 | |
| SCHEMBL13871907 | 0.76 | MAP3K5 (0.49) | CYP11B1CYP11B2 | |
| SCHEMBL13871887 | 0.75 | NOTUM (0.33) | NOTUMDRD2HTR6 | |
| SCHEMBL13872329 | 0.74 | HTR1A (0.34) | DRD2 | |
| SCHEMBL13871921 | 0.74 | ACHE (0.38) | NOTUMDRD2SLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009042907-A1 | ISOINDOLINE COMPOUNDS FOR THE TREATMENT OF SPINAL MUSCULAR ATROPHY AND OTHER USES | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2009-04-02 | — | — | WO | disclosed |