Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 4/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | THPO | P40225 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HTR7 | P34969 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13872297 | 0.93 | NPC1 (0.35) | HTR1AHTR2ANPC1RAB9ATP53 | |
| SCHEMBL13871879 | 0.82 | HTR2C (0.37) | HTR1AHTR2ATP53CYP1A2CYP3A4 | |
| SCHEMBL13871856 | 0.79 | CYP1A2 (0.35) | HTR2ACYP1A2CYP3A4CYP2D6NFKB1 | |
| SCHEMBL13871851 | 0.79 | NPC1 (0.37) | HTR1AHTR2ANPC1RAB9ATP53 | |
| SCHEMBL13871899 | 0.76 | MCHR1 (0.37) | DRD3DRD2DRD1 | |
| SCHEMBL13872307 | 0.76 | MAOA (0.37) | — | |
| SCHEMBL13871887 | 0.75 | NOTUM (0.33) | MAPTDRD3DRD2KDM4E | |
| SCHEMBL13871876 | 0.74 | NOTUM (0.35) | DRD2 | |
| SCHEMBL13871872 | 0.74 | BACE1 (0.36) | HTR2ACYP1A2CYP3A4CYP2D6NFKB1 | |
| SCHEMBL13871921 | 0.74 | ACHE (0.38) | HTR1AHTR2ATP53CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009042907-A1 | ISOINDOLINE COMPOUNDS FOR THE TREATMENT OF SPINAL MUSCULAR ATROPHY AND OTHER USES | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2009-04-02 | — | — | WO | disclosed |