Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 5/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 3/20 | 0.37 |
| ▸ | HTR2A | P28223 | 3/20 | 0.36 |
| ▸ | ACHE | P22303 | 2/20 | 0.36 |
| ▸ | HTR2B | P41595 | 2/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | CBLB | Q13191 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13871921 | 0.91 | ACHE (0.38) | HTR2CNOTUMHTR2AACHEHTR2B | |
| SCHEMBL13871856 | 0.85 | CYP1A2 (0.35) | HTR2CNOTUMHTR2AHTR2BMAPT | |
| SCHEMBL13871851 | 0.85 | NPC1 (0.37) | HTR2CNOTUMHTR2APOLBMAPT | |
| SCHEMBL13871899 | 0.82 | MCHR1 (0.37) | NOTUMMEN1KMT2ADRD2DRD1 | |
| SCHEMBL13872329 | 0.82 | HTR1A (0.34) | HTR2CHTR2AHTR2BMAPTTP53 | |
| SCHEMBL13871887 | 0.81 | NOTUM (0.33) | NOTUMMAPTDRD2MAPK1DRD3 | |
| SCHEMBL13871876 | 0.79 | NOTUM (0.35) | NOTUMSLC6A3KMT2ADRD2SLC6A2 | |
| SCHEMBL13871872 | 0.79 | BACE1 (0.36) | HTR2CNOTUMHTR2AHTR2BCYP3A4 | |
| SCHEMBL13872138 | 0.78 | HTR2C (0.37) | HTR2CHTR2AACHEPOLBCBLB | |
| SCHEMBL13872246 | 0.77 | CYP11B1 (0.43) | CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009042907-A1 | ISOINDOLINE COMPOUNDS FOR THE TREATMENT OF SPINAL MUSCULAR ATROPHY AND OTHER USES | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2009-04-02 | — | — | WO | disclosed |