Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | THPO | P40225 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.32 |
| ▸ | HTR2C | P28335 | 2/20 | 0.32 |
| ▸ | HTR2B | P41595 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13872329 | 0.93 | HTR1A (0.34) | NPC1CYP1A2RAB9ATP53CYP3A4 | |
| SCHEMBL13871921 | 0.80 | ACHE (0.38) | CYP1A2TP53CYP3A4CYP2D6TSHR | |
| SCHEMBL13871872 | 0.80 | BACE1 (0.36) | CYP1A2CYP3A4CYP2D6NFKB1HIF1A | |
| SCHEMBL13871851 | 0.78 | NPC1 (0.37) | NPC1RAB9ATP53CYP3A4CYP2D6 | |
| SCHEMBL13871879 | 0.76 | HTR2C (0.37) | CYP1A2TP53CYP3A4CYP2D6TSHR | |
| SCHEMBL12656575 | 0.75 | NPC1 (0.54) | NPC1CYP1A2RAB9ATP53CYP3A4 | |
| SCHEMBL13871887 | 0.74 | NOTUM (0.33) | MAPT | |
| SCHEMBL13871856 | 0.74 | CYP1A2 (0.35) | CYP1A2CYP3A4CYP2D6NFKB1HIF1A | |
| SCHEMBL13871899 | 0.71 | MCHR1 (0.37) | HSD17B3 | |
| SCHEMBL13871925 | 0.70 | DRD2 (0.34) | HTR1AHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009042907-A1 | ISOINDOLINE COMPOUNDS FOR THE TREATMENT OF SPINAL MUSCULAR ATROPHY AND OTHER USES | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2009-04-02 | — | — | WO | disclosed |