Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | AMY1A | P0DUB6 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.36 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.35 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.35 |
| ▸ | ERN1 | O75460 | 1/20 | 0.35 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31665009 | 0.82 | HTR2A (0.41) | TGFBR1MAPK14CSNK1DCSNK1EHTR2A | |
| SCHEMBL3848598 | 0.77 | MAPT (0.40) | AMY1AKDM4EALDH1A1POLBMAPT | |
| SCHEMBL31352811 | 0.75 | LMNA (0.45) | KDM4EALDH1A1POLBMAPTHTR2A | |
| SCHEMBL15885508 | 0.75 | TGFBR1 (0.49) | KDM4EALDH1A1MAPTTGFBR1MAPK14 | |
| SCHEMBL2273627 | 0.75 | LMNA (0.45) | KDM4EALDH1A1POLBMAPTHTR2A | |
| SCHEMBL3852011 | 0.74 | AMY1A (0.43) | AMY1AKDM4EALDH1A1PDGFRBERN1 | |
| SCHEMBL15885364 | 0.74 | L3MBTL1 (0.46) | KDM4EALDH1A1MAPTTGFBR1MAPK14 | |
| SCHEMBL1682483 | 0.72 | ERN1 (0.42) | AMY1AKDM4EALDH1A1POLBMAPT | |
| SCHEMBL1682501 | 0.72 | USP8 (0.37) | AMY1AKDM4EALDH1A1POLBMAPT | |
| SCHEMBL10340365 | 0.72 | AMY1A (0.50) | AMY1AALDH1A1MAPTERN1GRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2048142-A2 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | Eisai R&D Management Co., Ltd. (JP) | 2009-04-15 | — | — | EP | disclosed |