Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | HTR3A | P46098 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | MITF | O75030 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28219445 | 0.82 | ALDH1A1 (0.32) | MAPTLMNAALDH1A1HSD17B10MITF | |
| SCHEMBL6921270 | 0.82 | MAPT (0.42) | MAPTTP53LMNACYP1A2CYP3A4 | |
| SCHEMBL232990 | 0.79 | LMNA (0.41) | MAPTTP53LMNACYP1A2CYP3A4 | |
| SCHEMBL27822685 | 0.79 | TP53 (0.43) | MAPTTP53LMNACYP1A2CYP3A4 | |
| SCHEMBL30525098 | 0.78 | MAPK1 (0.39) | MAPTTP53LMNACYP1A2CYP3A4 | |
| SCHEMBL6760184 | 0.78 | MAPK1 (0.39) | MAPTTP53LMNACYP1A2CYP3A4 | |
| SCHEMBL31121635 | 0.77 | ADRA2C (0.34) | MAPTTP53LMNACYP1A2CYP3A4 | |
| SCHEMBL22557736 | 0.77 | ADRA2C (0.34) | MAPTTP53LMNACYP1A2CYP3A4 | |
| SCHEMBL1389126 | 0.75 | FGFR1 (0.42) | MAPTTP53LMNACYP1A2CYP3A4 | |
| SCHEMBL27933610 | 0.75 | KDM4E (0.35) | MAPTTP53LMNACYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020002177-A1 | Endothelin receptor antagonists | SMITHKLINE BEECHAM CORPORATION | 2002-01-03 | — | — | US | claimed |
| CN-1145223-A | Endothelin receptor antagonists | SMITHKLINE BEECHAM CORP (US) | 1997-03-19 | — | — | CN | claimed |
| JP-H08510211-A | — | — | 1996-10-29 | — | — | JP | claimed |
| CN-1124923-A | Endothelin receptor antagonists | SMITHKLINE BEECHAM CORP (US) | 1996-06-19 | — | — | CN | claimed |
| EP-0699069-A4 | — | — | 1996-04-03 | — | — | EP | claimed |
| EP-0699069-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1996-03-06 | — | — | EP | claimed |
| WO-1994025013-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1994-11-10 | — | — | WO | claimed |
| US-9902699-B2 | Synthesis of tetrahydroisoquinolines from 2-methyl-1-phenyl substituted indenes | Gregory Rosocha (CA) | 2018-02-27 | — | — | US | disclosed |
| EP-1180094-B1 | FUSED POLYCYCLIC AMINO ACIDS AS PHARMACEUTICAL AGENTS | WARNER LAMBERT CO (US) | 2004-07-28 | — | — | EP | disclosed |
| EP-1033130-B1 | INHIBITOR OF UROKINASE PRODUCTION AND OF ANGIOGENESIS AND ITS THERAPEUTIC USE | TAIHO PHARMACEUTICAL CO LTD (JP) | 2004-04-21 | — | — | EP | disclosed |
| CN-1129428-C | Endothelin receptor antagonists | SMITHKLINE BEECHAM CORP (US) | 2003-12-03 | — | — | CN | disclosed |
| US-6448260-B2 | 3-(2-CARBOXYMETHOXY-4-METHOXYPHENYL)-1-(3,4-METHYLENEDIOXY -PHENYL)-5-(PROP-1-YLOXY)-INDANE-2-CARBOXYLIC ACID AS AN ESPECIALLY PREFERRED COMPOUND; HYPOTENSIVE AGENTS; CARDIOVASCULAR, UROGENITAL AND RESPIRATORY DISORDERS | SMITHKLINE BEECHAM CORPORATION | 2002-09-10 | — | — | US | disclosed |
| US-6365610-B1 | 1,4-EPOXY-2,3-BENZODIOXEPINS OR 1,4-EPOXY-3,2-BENZOXAZEPINES | TAIHO PHARMACEUTICAL COMPANY LTD. (JP) | 2002-04-02 | — | — | US | disclosed |
| US-5719183-A | HYPOTENSIVE AGENTS; KIDNEY DISEASES; ANTIISCHEMIC AGENTS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-02-17 | — | — | US | disclosed |
| US-5719182-A | TREATING HYPERTENSION, RENAL FAILURE, CEREBROVASCULAR DISEASE | SMITHKLINE BEECHAM CORPORATION (US) | 1998-02-17 | — | — | US | disclosed |
| US-5716984-A | INDANE AND INDENE DERIVATIVES; TREATMENT OF CARDIOVASCULAR DISORDERS, KIDNEY DISORDERS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-02-10 | — | — | US | disclosed |
| CN-1124923-A | Endothelin receptor antagonists | SMITHKLINE BEECHAM CORP (US) | 1996-06-19 | — | — | CN | disclosed |
| EP-0699069-A4 | — | — | 1996-04-03 | — | — | EP | disclosed |
| EP-0699069-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1996-03-06 | — | — | EP | disclosed |
| WO-1994025013-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1994-11-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020002177-A1 | Endothelin receptor antagonists | EDNRA, EDNRB, ECE1 | MAPT 4431/4885TP53 4674/4885LMNA 2153/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.