SCHEMBL13879692

SCHEMBL13879692

COc1c(C)cnc(N)c1C

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AGXT P21549 1/20 0.55
DHFR P00374 3/20 0.42
NOS3 P29474 3/20 0.40
NOS2 P35228 3/20 0.40
NOS1 P29475 2/20 0.40
FYN P06241 2/20 0.40
HSP90AA1 P07900 5/20 0.39
TRAP1 Q12931 2/20 0.39
HSP90AB1 P08238 2/20 0.39
HSP90B1 P14625 1/20 0.39
USP7 Q93009 1/20 0.38
MEN1 O00255 1/20 0.36
SLC22A1 O15245 1/20 0.36
ALDH1A1 P00352 1/20 0.36
CYP3A4 P08684 1/20 0.36
TSHR P16473 1/20 0.36
NFKB1 P19838 1/20 0.36
CYP2C19 P33261 1/20 0.36
BLM P54132 1/20 0.36
KMT2A Q03164 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2679572 0.84 AGXT (0.47) AGXTDHFRNOS3NOS2NOS1
SCHEMBL22259302 0.79 DHFR (0.41) AGXTDHFRFYNUSP7MEN1
SCHEMBL2482691 0.79 NOS3 (0.48) NOS3NOS2NOS1HSP90AA1HSP90AB1
SCHEMBL94922 0.78 AGXT (0.50) AGXTDHFRHSP90AA1TRAP1HSP90AB1
SCHEMBL94923 0.77 AGXT (0.53) AGXTHSP90AA1TRAP1HSP90AB1HSP90B1
SCHEMBL5809638 0.77 NOS3 (0.46) AGXTDHFRNOS3NOS2NOS1
SCHEMBL29039529 0.76 AGXT (0.52) AGXTHSP90AA1TRAP1HSP90AB1HSP90B1
SCHEMBL7845798 0.76 AGXT (0.52) AGXTHSP90AA1TRAP1HSP90AB1HSP90B1
Hydrochloric Acid SCHEMBL28303939 0.76 AGXT (0.52) AGXTHSP90AA1TRAP1HSP90AB1HSP90B1
SCHEMBL29736023 0.76 AGXT (0.52) AGXTHSP90AA1TRAP1HSP90AB1HSP90B1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1973896-B1 A PROCESS FOR THE PREPARATION OF THE (S)-ENANTIOMER OF OMEPRAZOLE UNION QUIMICO FARMA (ES) 2009-04-15 EP disclosed