Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.35 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | IKBKB | O14920 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 5/20 | 0.33 |
| ▸ | NPC1 | O15118 | 5/20 | 0.33 |
| ▸ | RAB9A | P51151 | 5/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.33 |
| ▸ | RELA | Q04206 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13349613 | 0.79 | MAPT (0.36) | HTTMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL9706128 | 0.78 | HPGD (0.41) | HTTMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL18474287 | 0.76 | PRKCI (0.38) | HTTMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL13879940 | 0.76 | SIGMAR1 (0.37) | HTTMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL18077360 | 0.76 | KDM4E (0.49) | MAPTALDH1A1MEN1KMT2APOLB | |
| SCHEMBL28196867 | 0.76 | PDE2A (0.32) | — | |
| SCHEMBL23663756 | 0.75 | LMNA (0.30) | HTTLMNA | |
| SCHEMBL12494587 | 0.74 | GAA (0.31) | HTTMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL14138229 | 0.73 | CES2 (0.34) | HTTMAPTALDH1A1TDP1NPC1 | |
| SCHEMBL5510041 | 0.73 | ALDH1A1 (0.39) | HTTCCNE2CCNE1CDK2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582654-B2 | Heterocyclo inhibitors of potassium channel function | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-09-01 | — | — | US | disclosed |