Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 10/20 | 0.86 |
| ▸ | HTR7 | P34969 | 9/20 | 0.86 |
| ▸ | HTR2A | P28223 | 3/20 | 0.86 |
| ▸ | HTR2C | P28335 | 2/20 | 0.86 |
| ▸ | DRD2 | P14416 | 5/20 | 0.80 |
| ▸ | DRD4 | P21917 | 1/20 | 0.80 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.80 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.80 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.80 |
| ▸ | DRD3 | P35462 | 1/20 | 0.80 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.80 |
| ▸ | HTR2B | P41595 | 1/20 | 0.80 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.80 |
| ▸ | ADRA2A | P08913 | 5/20 | 0.77 |
| ▸ | HTR6 | P50406 | 3/20 | 0.77 |
| ▸ | NPC1 | O15118 | 1/20 | 0.61 |
| ▸ | TP53 | P04637 | 1/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.61 |
| ▸ | TSHR | P16473 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4776843 | 0.92 | HTR1A (0.94) | HTR1AHTR7HTR2AHTR2CDRD2 | |
| SCHEMBL13944278 | 0.91 | HTR1A (0.78) | HTR1AHTR7HTR2AHTR2CDRD2 | |
| SCHEMBL13944277 | 0.89 | HTR1A (0.78) | HTR1AHTR7HTR2AHTR2CDRD2 | |
| SCHEMBL12672472 | 0.83 | HTR7 (0.83) | HTR1AHTR7HTR2AHTR2CDRD2 | |
| SCHEMBL8577935 | 0.80 | DRD2 (0.72) | HTR1AHTR7HTR2AHTR2CDRD2 | |
| SCHEMBL3162960 | 0.80 | DRD2 (0.76) | DRD2DRD4DRD3SLC6A4KCNH2 | |
| SCHEMBL6526368 | 0.80 | DRD2 (0.85) | HTR1AHTR7HTR2ADRD2ADRA1D | |
| SCHEMBL9567514 | 0.80 | DRD2 (0.67) | HTR1AHTR7HTR2AHTR2CDRD2 | |
| SCHEMBL9567518 | 0.79 | DRD2 (0.66) | HTR1ADRD2DRD4ADRA1DADRA1A | |
| SCHEMBL8980634 | 0.79 | HTR7 (0.67) | HTR1AHTR7HTR2AHTR2CDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-H09500883-A | — | — | 1997-01-28 | — | — | JP | claimed |
| CN-1132508-A | Piperazine derivatives | REORDATI IND CHIMICA E FARMACE (CH) | 1996-10-02 | — | — | CN | claimed |
| EP-0711288-A1 | PIPERAZINE DERIVATIVES AS ALPHA 1A-ADRENERGIC RECEPTOR ANTAGONISTS | RECORDATI INDUSTRIA CHIMICA E FARMACEUTICA S.p.a. (IT) | 1996-05-15 | — | — | EP | claimed |
| WO-1995004049-A1 | PIPERAZINE DERIVATIVES AS α1A-ADRENERGIC RECEPTOR ANTAGONISTS | RECORDATI S.A., CHEMICAL AND PHARMACEUTICAL COMPANY (CH) | 1995-02-09 | — | — | WO | claimed |
| EP-0711288-A1 | PIPERAZINE DERIVATIVES AS ALPHA 1A-ADRENERGIC RECEPTOR ANTAGONISTS | RECORDATI INDUSTRIA CHIMICA E FARMACEUTICA S.p.a. (IT) | 1996-05-15 | — | — | EP | disclosed |
| WO-1995004049-A1 | PIPERAZINE DERIVATIVES AS α1A-ADRENERGIC RECEPTOR ANTAGONISTS | RECORDATI S.A., CHEMICAL AND PHARMACEUTICAL COMPANY (CH) | 1995-02-09 | — | — | WO | disclosed |